Literature DB >> 682210

Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 ppm.

C A Synder, B D Goldstein, A Sellakumar, S R Wolman, I Bromberg, M N Erlichman, S Laskin.   

Abstract

Sprague-Dawley rats and AKR/J mice were exposed to 300 ppm benzene vapor for 6 h/d, 5 d/wk, for life. Rats exhibited lymphocytopenia, mild anemia, and moderately decreased survival. Mice showed severe lymphocytopenia and anemia accompanied by granulocytosis and reticulocytosis. Treated mice also showed significantly decreased survival and weight gain. No indications of a leukemic or preleukemic response were observed in either species.

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Year:  1978        PMID： 682210     DOI： 10.1080/15287397809529683

Source DB:  PubMed          Journal:  J Toxicol Environ Health        ISSN： 0098-4108


  15 in total

Review 1.  The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Authors:  Scott M Arnold; Juergen Angerer; Peter J Boogaard; Michael F Hughes; Raegan B O'Lone; Steven H Robison; A Robert Schnatter
Journal:  Crit Rev Toxicol       Date:  2013-02       Impact factor: 5.635

2.  Evidence for strain-specific differences in benzene toxicity as a function of host target cell susceptibility.

Authors:  D J Neun; A Penn; C A Snyder
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

3.  Protracted benzene exposure causes a proliferation of myeloblasts and/or promyelocytes in CD-1 mice.

Authors:  C A Snyder; J D Green; J LoBue; B D Goldstein; C D Valle; R E Albert
Journal:  Bull Environ Contam Toxicol       Date:  1981-07       Impact factor: 2.151

4.  Toxicity of chronic benzene inhalation: CD-1 mice exposed to 300 ppm.

Authors:  C A Snyder; B D Goldstein; A Sellakumar; I Bromberg; S Laskin; R E Albert
Journal:  Bull Environ Contam Toxicol       Date:  1982-10       Impact factor: 2.151

5.  Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure.

Authors:  A M Dempster; C A Snyder
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

6.  The carcinogenicity of discontinuous inhaled benzene exposures in CD-1 and C57Bl/6 mice.

Authors:  C A Snyder; A R Sellakumar; D J James; R E Albert
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

7.  Erythroid progenitor cells that survive benzene exposure exhibit greater resistance to the toxic benzene metabolites benzoquinone and hydroquinone.

Authors:  D J Neun; A Penn; C A Snyder
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

8.  A prospective study in the Australian petroleum industry. II. Incidence of cancer.

Authors:  D Christie; K Robinson; I Gordon; J Bisby
Journal:  Br J Ind Med       Date:  1991-08

9.  The vanishing zero revisited: thresholds in the age of genomics.

Authors:  Helmut Zarbl; Michael A Gallo; James Glick; Ka Yee Yeung; Paul Vouros
Journal:  Chem Biol Interact       Date:  2010-01-28       Impact factor: 5.192

10.  The fate of benzene-oxide.

Authors:  Terrence J Monks; Michael Butterworth; Serrine S Lau
Journal:  Chem Biol Interact       Date:  2009-12-29       Impact factor: 5.192
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