Literature DB >> 6821557

Cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ARA-C.

J L Krahenbuhl1, J S Remington.   

Abstract

Studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with Corynebacterium parvum revealed that their effect on the EMT-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. In additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on EMT-6 target cells.

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Year:  1980        PMID： 6821557     DOI： 10.3109/08923978009046465

Source DB:  PubMed          Journal:  J Immunopharmacol        ISSN： 0163-0571


  5 in total

1.  Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.

Authors:  J L Krahenbuhl; S D Sharma; R W Ferraresi; J S Remington
Journal:  Infect Immun       Date:  1981-02       Impact factor: 3.441

2.  Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan.

Authors:  L D Sibley; L B Adams; J L Krahenbuhl
Journal:  Clin Exp Immunol       Date:  1990-04       Impact factor: 4.330

3.  Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.

Authors:  L D Sibley; J L Krahenbuhl
Journal:  Infect Immun       Date:  1988-08       Impact factor: 3.441

4.  Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

Authors:  D L Granger; J B Hibbs; J R Perfect; D T Durack
Journal:  J Clin Invest       Date:  1988-04       Impact factor: 14.808

5.  Mycobacterial lipoarabinomannan inhibits gamma interferon-mediated activation of macrophages.

Authors:  L D Sibley; S W Hunter; P J Brennan; J L Krahenbuhl
Journal:  Infect Immun       Date:  1988-05       Impact factor: 3.441
  5 in total

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