Antibacterial activities of Candida yeasts. Partial purification and characterization of the active substance of Candida guilliermondii.

The activity spectra of 25 Candida strains on strains of different species of bacteria were recorded. The active substance produced by Candida guilliermondii strain 848 was partially purified by cation exchange and chromatography gel filtration on Sephadex G-15. The substance is heat stable (80 degrees C, 10 min), not susceptible to treatment with proteases and most probably of a molecular weight smaller than 3500 Dalton. At a concentration of 50 A.U./ml it acts bacteriostatically on a Staphylococcus epidermidis strain (Fig. 1).