| Literature DB >> 6820483 |
Abstract
After ablation of mesolimbic and mesocortical dopaminergic neurons produced by 6-hydroxydopamine (6-OHDA) injections in the anterolateral hypothalamus, rats investigate a novel object less. Systemic administration of the dopamine (DA) agonist apomorphine increases investigatory movements in these DA-denervated rats when the object is novel, but not when the object is familiar. Pimozide pretreatment prevents the increased investigation produced by apomorphine in DA-denervated rats. These findings suggest that mesolimbic and mesocortical DA neurons are necessary for normal exploratory behavior in the rat.Entities:
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Year: 1980 PMID： 6820483 DOI： 10.1016/0304-3940(80)90062-2
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046