Literature DB >> 6820442

Role of the liver in the pathogenesis of cerebral disorders in phenylketonuria.

Y I Barashnev, V V Korneichuk, A I Klembovsky, L A Klyushina.   

Abstract

Comprehensive studies on structure and function of the liver (biochemical profiles, light and electron microscopy, determination of phenylalanine hydroxylase activity) were performed in children with phenylketonuria (PKU). It was established that the liver is always involved in the pathological process. Comparison of results obtained with peculiarities of neuropsychiatric disorders revealed a dependence of the initial manifestations and the severity of PKU on the extent of enzyme deficiency. Amino acid disorders and abnormal lipid metabolism both contribute to the genesis of cerebral lesions.

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Year:  1982        PMID： 6820442     DOI： 10.1007/bf02179142

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  15 in total

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  4 in total

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  4 in total

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