Literature DB >> 6819771

Enhancement of lymphocyte activation by BW755C in vitro.

A T Ali, J Morley.   

Abstract

BW755C considerably enhances the increased DNA synthesis of lymphocytes responding to mitogen stimulation. This effect is evident at much lower concentrations of BW755C than are required to inhibit cyclooxygenase or lipoxygenase enzymes. This suggests that in vivo effects of BW755C may not solely depend upon modification of arachidonic acid metabolism.

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Year:  1982        PMID： 6819771     DOI： 10.1007/bf01965073

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  19 in total

1.  A new approach to anti-inflammatory drugs.

Authors:  G A Higgs; R J Flower; J R Vane
Journal:  Biochem Pharmacol       Date:  1979-06-15       Impact factor: 5.858

2.  Control of lymphokine secretion by prostaglandins.

Authors:  D Gordon; M A Bray; J Morley
Journal:  Nature       Date:  1976-07-29       Impact factor: 49.962

3.  Effects of acetaminophen on normal human peripheral blood lymphocytes: enhancement of mitogen- and antigen-stimulated incorporation of tritiated thymidine.

Authors:  R S Panush; S J Ossakow
Journal:  Clin Exp Immunol       Date:  1979-12       Impact factor: 4.330

4.  Inhibitors of prostaglandin synthetase block the generation of suppressor T cells induced by concanavalin A.

Authors:  I M Orme; F L Shand
Journal:  Int J Immunopharmacol       Date:  1981

5.  The production and characterisation of products of the lipoxygenase enzyme system released by rat peritoneal macrophages.

Authors:  M V Doig; A W Ford-Hutchinson
Journal:  Prostaglandins       Date:  1980-12

6.  Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis.

Authors:  F Hirata; S Toyoshima; J Axelrod; M J Waxdal
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

7.  Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation.

Authors:  J S Goodwin; R P Messner; G T Peake
Journal:  J Clin Invest       Date:  1978-10       Impact factor: 14.808

8.  Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.

Authors:  M Hamberg; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

9.  Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

Authors:  J S Goodwin; A D Bankhurst; R P Messner
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

10.  Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.

Authors:  R W Dutton
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307
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  1 in total

1.  Effects of non-steroidal anti-inflammatory drugs on lymphocyte activation.

Authors:  A T Ali; J M Hanson; J Morley
Journal:  Agents Actions       Date:  1984-02
  1 in total

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