Literature DB >> 6819770

Further studies on the effects of disodium cromoglycate on guinea pig ileum.

M de Lourdes Arruzazabala, R G Alvarez.   

Abstract

Transmural electrical stimulation was carried out on innervated strips of the longitudinal muscle of guinea pig ileum. Disodium cromoglycate (DSCG) inhibited the electrically induced contractions. Five minutes later, prostaglandin E2 (2.5 ng/ml) was added to the bath and it reversed the action of DSCG. Furthermore, DSCG inhibits significantly the guinea pig ileum contractions induced by nicotine and also those induced by histamine and acetylcholine on ileum denervated by cooling. These results suggest that DSCG effects on guinea pig ileum contraction are mediated by membrane-stabilizing properties of this drug on smooth muscle fibres as well as on myenteric plexus.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6819770     DOI： 10.1007/bf01965066

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

1.  Interaction of drugs and the effect of cooling on the isolated mammalian intestine.

Authors:  N Ambache
Journal:  J Physiol       Date:  1946-01-15       Impact factor: 5.182

2.  Protective effect of disodium cromoglycate on rat peritoneal mast cells.

Authors:  R Marshall
Journal:  Thorax       Date:  1972-01       Impact factor: 9.139

3.  Comparison of in vivo and in vitro inhibition of the anaphylactic mechanism by beta-adrenergic stimulants and disodium cromoglycate.

Authors:  E S Assem; A W Richter
Journal:  Immunology       Date:  1971-11       Impact factor: 7.397

4.  Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms.

Authors:  J S Cox
Journal:  Nature       Date:  1967-12-30       Impact factor: 49.962

5.  The effects of antiinflammatory steroids on the response of the guinea-pig isolated ileum to acetylcholine, histamine, nicotine, 5-hydroxytryptamine and electrical stimulation.

Authors:  J P Famaey; J Fontaine; I Seaman; J Reuse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-11       Impact factor: 3.000

Review 6.  Review of clinical activity and mode of action of sodium cromoglycate.

Authors:  R E Altounyan
Journal:  Clin Allergy       Date:  1980-07

7.  Cromoglycate and other antiallergic drugs: a possible mechanism of action.

Authors:  J C Foreman; L G Garland
Journal:  Br Med J       Date:  1976-04-03

8.  Plasma levels and urinary excretion of disodium cromoglycate afer inhalation by human volunteers.

Authors:  G F Moss; K M Jones; J T Ritchie; J S Cox
Journal:  Toxicol Appl Pharmacol       Date:  1971-10       Impact factor: 4.219

9.  Sensitization of the smooth muscle by prostaglandin E1 contributes to reversal of drug-induced inhibition of the guinea-pig ileum.

Authors:  R Schulz; C Cartwright
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-09       Impact factor: 3.000

10.  New light on the mechanism of action of disodium cromoglycate.

Authors:  R G Alvarez; W Kazimierczak
Journal:  Agents Actions       Date:  1981-04
View more
  2 in total

1.  Effects of cromolyn sodium on isolated rat's trachea.

Authors:  Yuan-Yung Lin; Ying-Liang Chou; Yueng-Hsiang Chu; Chi-Chung Wu; Jia-Yi Wang; Hsing-Won Wang
Journal:  Allergy Rhinol (Providence)       Date:  2011-04

2.  Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.

Authors:  Siobhan Yvonne Carroll; Siobhain Mary O'Mahony; Susan Grenham; John Francis Cryan; Niall Patrick Hyland
Journal:  PLoS One       Date:  2013-12-18       Impact factor: 3.240
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.