Literature DB >> 6819280

The myxovirescins, a family of antibiotics from Myxococcus virescens (Myxobacterales).

K Gerth, H Irschik, H Reichenbach, W Trowitzsch.   

Abstract

The myxobacterium, Myxococcus virescens strain Mx v48 produced a family of at least 12 closely related antibiotics, the myxovirescins. At a concentration of 1 to 5 micrograms/ml, the main component, myxovirescin A, was bactericidal for many Gram-negative bacteria, in particular enterobacteria, and at 20 to 50 micrograms/ml it also inhibited some pseudomonads and Gram-positive bacteria. The antibiotics seem to interfere with cell wall synthesis. The molecular formula of myxovirescin A was C35H61NO8. It is a new antibiotic.

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Year:  1982        PMID: 6819280     DOI: 10.7164/antibiotics.35.1454

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  15 in total

1.  Membrane localization of motility, signaling, and polyketide synthetase proteins in Myxococcus xanthus.

Authors:  Vesna Simunovic; Frank C Gherardini; Lawrence J Shimkets
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

2.  Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.

Authors:  Christopher T Calderone; David F Iwig; Pieter C Dorrestein; Neil L Kelleher; Christopher T Walsh
Journal:  Chem Biol       Date:  2007-07

3.  Antibiotic production by myxobacteria plays a role in predation.

Authors:  Yao Xiao; Xueming Wei; Richard Ebright; Daniel Wall
Journal:  J Bacteriol       Date:  2011-07-15       Impact factor: 3.490

4.  Genetic redundancy, proximity, and functionality of lspA, the target of antibiotic TA, in the Myxococcus xanthus producer strain.

Authors:  Yao Xiao; Daniel Wall
Journal:  J Bacteriol       Date:  2014-01-03       Impact factor: 3.490

5.  Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase.

Authors:  Yao Xiao; Klaus Gerth; Rolf Müller; Daniel Wall
Journal:  Antimicrob Agents Chemother       Date:  2012-01-09       Impact factor: 5.191

6.  Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli.

Authors:  Sabrina Mühlen; Viktor A Zapol'skii; Ursula Bilitewski; Petra Dersch
Journal:  Antimicrob Agents Chemother       Date:  2021-09-20       Impact factor: 5.191

7.  Identification of Functions Affecting Predator-Prey Interactions between Myxococcus xanthus and Bacillus subtilis.

Authors:  Susanne Müller; Sarah N Strack; Sarah E Ryan; Mary Shawgo; Abigail Walling; Susanna Harris; Chris Chambers; Jennifer Boddicker; John R Kirby
Journal:  J Bacteriol       Date:  2016-11-18       Impact factor: 3.490

8.  Mutation and mapping of genes involved in production of the antibiotic TA in Myxococcus xanthus.

Authors:  M Varon; N Fuchs; M Monosov; S Tolchinsky; E Rosenberg
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191

9.  Bacillaene and sporulation protect Bacillus subtilis from predation by Myxococcus xanthus.

Authors:  Susanne Müller; Sarah N Strack; B Christopher Hoefler; Paul D Straight; Daniel B Kearns; John R Kirby
Journal:  Appl Environ Microbiol       Date:  2014-07-07       Impact factor: 4.792

10.  Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity.

Authors:  Daniel Krug; Gabriela Zurek; Ole Revermann; Michiel Vos; Gregory J Velicer; Rolf Müller
Journal:  Appl Environ Microbiol       Date:  2008-03-31       Impact factor: 4.792

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