Literature DB >> 6818317

Mutant monoclonal antibodies with alterations in biological functions.

D E Yelton, M D Scharff.   

Abstract

Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.

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Year:  1982        PMID： 6818317      PMCID： PMC2186830          DOI： 10.1084/jem.156.4.1131

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  36 in total

1.  The interaction between protein A and immunoglobulin G as studied with the Fc-fragment of a myeloma protein by circular dichroism.

Authors:  I Shöholm
Journal:  FEBS Lett       Date:  1975-03-15       Impact factor: 4.124

2.  Mutations in immunoglobulin-producing mouse myeloma cells.

Authors:  R Baumal; B K Birshtein; P Coffino; M D Scharff
Journal:  Science       Date:  1973-10-12       Impact factor: 47.728

3.  Variants of mouse myeloma cells that produce short immunoglobulin heavy chains.

Authors:  B K Birshtein; J L Preud'homme; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

4.  Antiphagocytic effects of staphylococcal protein A.

Authors:  J H Dossett; G Kronvall; R C Williams; P G Quie
Journal:  J Immunol       Date:  1969-12       Impact factor: 5.422

5.  A simplified method for cyanogen bromide activation of agarose for affinity chromatography.

Authors:  S C March; I Parikh; P Cuatrecasas
Journal:  Anal Biochem       Date:  1974-07       Impact factor: 3.365

6.  Growth of primary plasmacytomas in the mineral oil-conditioned peritoneal environment.

Authors:  M Potter; J G Pumphrey; J L Walters
Journal:  J Natl Cancer Inst       Date:  1972-07       Impact factor: 13.506

7.  Mouse myeloma mutants blocked in the assembly, glycosylation and secretion of immunoglobulin.

Authors:  S Weitzman; M D Scharff
Journal:  J Mol Biol       Date:  1976-04-05       Impact factor: 5.469

8.  A hemagglutination inhibition technique for detection of immunoglobulins in supernatants of human lymphoblastoid cell lines.

Authors:  J Evans; M Steel; E Arthur
Journal:  Cell       Date:  1974-10       Impact factor: 41.582

9.  Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.

Authors:  S K Pierce; N R Klinman
Journal:  J Exp Med       Date:  1976-11-02       Impact factor: 14.307

10.  Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits.

Authors:  R Laskov; M D Scharff
Journal:  J Exp Med       Date:  1970-03-01       Impact factor: 14.307
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  8 in total

1.  Monoclonal antibodies: a potentially powerful tool in the diagnosis and treatment of infectious diseases.

Authors:  G Spira; R R Pollock; A Bargellesi; M D Scharff
Journal:  Eur J Clin Microbiol       Date:  1985-06       Impact factor: 3.267

2.  Expression and characterization of an antibody binding specificity joined to insulin-like growth factor 1: potential applications for cellular targeting.

Authors:  S U Shin; S L Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

3.  Identification of mutant monoclonal antibodies with increased antigen binding.

Authors:  R R Pollock; D L French; M L Gefter; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

4.  High rates of deletions in the constant region segment of the immunoglobulin mu gene.

Authors:  H M Jäck; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

5.  Different ways to modify monoclonal antibodies.

Authors:  G Köhler; B Baumann; A Iglesias; J McCubrey; M J Potash; A Traunecker; D Zhu
Journal:  Med Oncol Tumor Pharmacother       Date:  1984

6.  Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

Authors:  B Baumann; M J Potash; G Köhler
Journal:  EMBO J       Date:  1985-02       Impact factor: 11.598

7.  Frequent biclonality and Ig gene alterations among B cell lymphomas that show multiple histologic forms.

Authors:  M H Siegelman; M L Cleary; R Warnke; J Sklar
Journal:  J Exp Med       Date:  1985-04-01       Impact factor: 14.307

8.  Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

Authors:  L Hendershot; D Bole; G Köhler; J F Kearney
Journal:  J Cell Biol       Date:  1987-03       Impact factor: 10.539
  8 in total

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