Literature DB >> 6817914

Failure of ascorbic acid to inhibit growth of transplantable and dimethylbenzanthracene induced rat mammary tumors.

Y J Abul-Hajj, M Kelliher.   

Abstract

The effect of ascorbic acid on the growth of 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumor and on growth of R3230AC and MT/W9a-B transplantable rat mammary tumors was investigated. High doses of ascorbic acid averaging about 540 mg/day/rat administered orally in drinking water had no effect on the growth of both R3230A and MT/W9a-B transplantable mammary tumors. Furthermore, vitamin C was unable to postpone tumor induction, reduce tumor incidence or prolong survival time of rats treated with DMBA.

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Year:  1982        PMID: 6817914     DOI: 10.1016/0304-3835(82)90110-0

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  3 in total

Review 1.  Nutrition and breast cancer.

Authors:  D J Hunter; W C Willett
Journal:  Cancer Causes Control       Date:  1996-01       Impact factor: 2.506

2.  [Vitamin C in a long-term trial is without effect on experimental carcinogenesis].

Authors:  B Werner; K Hrynyschyn; H Schäfer
Journal:  Langenbecks Arch Chir       Date:  1985

Review 3.  Ascorbate on cell growth and differentiation.

Authors:  F J Alcaín; M I Burón
Journal:  J Bioenerg Biomembr       Date:  1994-08       Impact factor: 2.945

  3 in total

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