Clinical consequences of low selenium intake and its relationship to vitamin E.

Great differences in dietary selenium intake have resulted in naturally occurring human selenium deficiencies and toxicities in certain parts of the world. Most North American diets, however, provide levels of selenium that fall within the estimated safe and adequate range of intake (50 to 200 microgram/day for adults) as established by the U.S. National Research Council. Low selenium status may develop in individuals fed certain therapeutic diets or given total parenteral nutrition. Attempts have been made to link low selenium intake with cancer and heart disease, but additional research is needed in this area. Selenium, as a constituent of glutathione peroxidase, plays a role in the antioxidant defense systems of the body, but other metabolic roles for selenium may yet be discovered.