Literature DB >> 6815667

Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.

M Schweri, M Cain, J Cook, S Paul, P Skolnick.   

Abstract

The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-beta-carboline (beta-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of beta-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

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Year:  1982        PMID： 6815667     DOI： 10.1016/0091-3057(82)90304-5

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  8 in total

1.  Cerebral-activating (EEG) properties of two inverse agonists and of an antagonist at the benzodiazepine receptor in the rat.

Authors:  V Santucci; M Fournier; P Worms; P Keane; K Bizière
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

2.  Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist.

Authors:  L H Jensen; E N Petersen; C Braestrup; T Honoré; W Kehr; D N Stephens; H Schneider; D Seidelmann; R Schmiechen
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.

Authors:  Wenyuan Yin; Samarpan Majumder; Terry Clayton; Steven Petrou; Michael L VanLinn; Ojas A Namjoshi; Chunrong Ma; Brett A Cromer; Bryan L Roth; Donna M Platt; James M Cook
Journal:  Bioorg Med Chem       Date:  2010-09-29       Impact factor: 3.641

4.  The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock.

Authors:  S F Maier; R E Grahn; S Maswood; L R Watkins
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

5.  Reduction of flurazepam convulsive threshold by Ro 15-1788.

Authors:  W M Bourn; R L Garrett; C E Reigel; F O Risinger
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

6.  Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish.

Authors:  Oihane Jaka; Iñaki Iturria; Marco van der Toorn; Jorge Hurtado de Mendoza; Diogo A R S Latino; Ainhoa Alzualde; Manuel C Peitsch; Julia Hoeng; Kyoko Koshibu
Journal:  Front Pharmacol       Date:  2021-05-13       Impact factor: 5.810

7.  Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor.

Authors:  Adrian Handforth
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-09-12

Review 8.  The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.

Authors:  Barbara Kosmowska; Jadwiga Wardas
Journal:  Biomolecules       Date:  2021-12-02
  8 in total

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