Does the X chromosome have a special role in immune biology?

The observation that a number of gene clusters or "supergenes" are critical in the genetic regulation of the immune response was used to introduce the hypothesis that multiple X chromosome genes are similarly organized and that they play some special critical role in the immune response. The evidence discussed included current information on several of the human X-linked immune deficiencies, data from mice and studies suggesting X chromosome genes have "regulatory" functions in non-immune tissues. A set of potentially testable speculations based on the hypothesis were advanced.