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Literature DB >> 6814598

Decreased plasma motilin concentrations in pregnancy.

N D Christofides, M A Ghatei, S R Bloom, C Borberg, M D Gillmer.

Abstract

Plasma motilin concentrations were measured in 37 women during the second and third trimester of pregnancy and one week after delivery. The mean plasma motilin concentrations, both fasting and after a glucose load and a mixed meal, were significantly (p less than 0.001) reduced during pregnancy, returning to the normal range one week post partum. Pregnancy appears to have a profound inhibitory effect on plasma motilin, and this may in part be responsible for the gastrointestinal hypomotility associated with pregnancy.

Entities: Chemical Disease Gene Species

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Year: 1982 PMID： 6814598 PMCID： PMC1500630 DOI： 10.1136/bmj.285.6353.1453

Source DB: PubMed Journal: Br Med J (Clin Res Ed) ISSN： 0267-0623

14 in total

7. Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders.

Authors: D M Preston; T E Adrian; N D Christofides; J E Lennard-Jones; S R Bloom
Journal: Gut Date: 1985-10 Impact factor: 23.059

8. Gastric pH and volume after oral fluids in the postpartum patient.

Authors: K K Lam; H Y So; T Gin
Journal: Can J Anaesth Date: 1993-03 Impact factor: 5.063

Review 9. Pregnancy-related constipation.

Authors: Charlene M Prather
Journal: Curr Gastroenterol Rep Date: 2004-10

Review 10. Routine prophylactic drugs in normal labour for reducing gastric aspiration and its effects.

Authors: G M L Gyte; Y Richens
Journal: Cochrane Database Syst Rev Date: 2006-07-19

Decreased plasma motilin concentrations in pregnancy.

1. Heartburn in pregnancy--a manometric study.

2. Gallbladder emptying during the normal menstrual cycle. A cholecystographic study.

3. Obesity in pregnancy: the effect of dietary advice.

4. The sluggish gallbladder of pregnancy.

5. Progesterone effects on three regional gastrointestinal tissues.

6. Motilin and the interdigestive migrating motor complex in man.

7. Inhibition of lower esophageal sphincter circular muscle by female sex hormones.

8. Effect of motilin on the rate of gastric emptying and gut hormone release during breakfast.

9. Release of motilin by oral and intravenous nutrients in man.

10. Motilin-induced mechanical activity in the canine alimentary tract.

Review 1. [Fetomaternal pharmacology : anesthesiological approach in surgical interventions during pregnancy].

2. The nutritional consequences of pregnancy sickness : A critique of a hypothesis.

3. Changes in bowel function: pregnancy and the puerperium.

4. Bowel function and transit rate during the menstrual cycle.

5. Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy.

6. Bowel function measurements of individuals with different eating patterns.

7. Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders.

8. Gastric pH and volume after oral fluids in the postpartum patient.

Review 9. Pregnancy-related constipation.

Review 10. Routine prophylactic drugs in normal labour for reducing gastric aspiration and its effects.