Literature DB >> 6814425

The kinetic mechanism of the major form of ox kidney aldehyde reductase with D-glucuronic acid.

A K Daly, T J Mantle.   

Abstract

The steady-state kinetics of the major form of ox kidney aldehyde reductase with d-glucuronic acid have been determined at pH7. Initial rate and product inhibition studies performed in both directions are consistent with a Di-Iso Ordered Bi Bi mechanism. The mechanism of inhibition by sodium valproate and benzoic acid is shown to involve flux through an alternative pathway.

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Year:  1982        PMID： 6814425      PMCID： PMC1158491          DOI： 10.1042/bj2050381

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain.

Authors:  S R Whittle; A J Turner
Journal:  J Neurochem       Date:  1978-12       Impact factor: 5.372

2.  Inhibition of aldehyde reductase by acidic metabolites of the biogenic amines.

Authors:  A J Turner; P E Hick
Journal:  Biochem Pharmacol       Date:  1975-09-15       Impact factor: 5.858

3.  Inhibition of aldehyde reductase isoenzymes in human and rat brain.

Authors:  M M Ris; R A Deitrich; J P Von Wartburg
Journal:  Biochem Pharmacol       Date:  1975-10-15       Impact factor: 5.858

4.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-01-08

5.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

6.  Glutamic dehydrogenase. III. The order of substrate addition in the enzymatic reaction.

Authors:  C FRIEDEN
Journal:  J Biol Chem       Date:  1959-11       Impact factor: 5.157

7.  Lactic dehydrogenase. IV. The influence of pH on the kinetics of the reaction.

Authors:  A D WINER; G W SCHWERT
Journal:  J Biol Chem       Date:  1958-04       Impact factor: 5.157

8.  Kinetics and mechanism of action of aldehyde reductase from pig kidney.

Authors:  W S Davidson; T G Flynn
Journal:  Biochem J       Date:  1979-02-01       Impact factor: 3.857

9.  Structure-function relationships in lactate dehydrogenase.

Authors:  M J Adams; M Buehner; K Chandrasekhar; G C Ford; M L Hackert; A Liljas; M G Rossmann; I E Smiley; W S Allison; J Everse; N O Kaplan; S S Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

10.  Cytoplasmic aldo-keto reductases: a class of drug metabolizing enzymes.

Authors:  N R Bachur
Journal:  Science       Date:  1976-08-13       Impact factor: 47.728
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  3 in total

1.  The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.

Authors:  Pierre Morieux; Christophe Salomé; Ki Duk Park; James P Stables; Harold Kohn
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

2.  Kinetic mechanism of pulmonary carbonyl reductase.

Authors:  K Matsuura; T Nakayama; M Nakagawa; A Hara; H Sawada
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

3.  Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase.

Authors:  K S De Jongh; P J Schofield; M R Edwards
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857
  3 in total

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