| Literature DB >> 6814025 |
E Karbe, M Böttger, P P McCann, A Sjoerdsma, E K Freitas.
Abstract
The curative effect of alpha-difluoromethylornithine (DFMO) on fatal T. congolense infection in mice was investigated using various concentrations administered orally in drinking water. Permanent cure was achieved in mice receiving 4% for 3 days or 2% for 5 days. Mice receiving less became parasitemic again but then, without any further treatment, resisted death due to trypanosomes for an average of 34.5 days, while untreated controls were dead within 8 days after trypanosomes were first seen in their blood.Entities:
Mesh：
Substances：
Year: 1982 PMID： 6814025
Source DB: PubMed Journal: Tropenmed Parasitol ISSN： 0303-4208