Literature DB >> 6814007

HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.

L Contu, I Deschamps, H Lestradet, J Hors, M Schmid, M Busson, A Benajam, A Marcelli-Barge, J Dausset.   

Abstract

R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.

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Year:  1982        PMID： 6814007     DOI： 10.1111/j.1399-0039.1982.tb00335.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  24 in total

1.  The HLA component of type I diabetes.

Authors:  F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  2000-04       Impact factor: 11.025

2.  Genetic structure of the novel low-frequency haplotype HLA-B49, SC01, DR4 and its contribution to insulin-dependent diabetes susceptibility.

Authors:  O G Segurado; P Iglesias-Casarrubios; P Morales; J Martínez-Laso; J Partanen; R D Campbell; A Arnaiz-Villena
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

3.  A novel HLA-DR4 haplotype generated by a rare recombinational event between DRB1 and DQA1 loci.

Authors:  C Carcassi; R Giorda; M Trucco; L Contu
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

4.  HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A negative association with DR5 rather than DR2?

Authors:  C Maffeis; S Ciaffoni; E Gonfiatini; C Roata; L Pinelli
Journal:  Acta Diabetol Lat       Date:  1990 Jul-Sep

5.  HLA antigens in Spanish type 1 diabetic population. Correlations with clinical, biological and autoimmune markers.

Authors:  A Goday; E Motaña; G Ercilla; J Fernandez; R Gomis; E Vilardell
Journal:  Acta Diabetol Lat       Date:  1990 Jul-Sep

6.  Two distinct HLA-DR3 haplotypes are associated with age related heterogeneity in type 1 (insulin-dependent) diabetes.

Authors:  I Deschamps; A Marcelli-Barge; J C Poirier; O Cohen-Haguenauer; H Abderrahim; D Cohen; H Lestradet; J Hors
Journal:  Diabetologia       Date:  1988-12       Impact factor: 10.122

7.  The "Sardinian" HLA-A30,B18,DR3,DQw2 haplotype constantly lacks the 21-OHA and C4B genes. Is it an ancestral haplotype without duplication?

Authors:  L Contu; C Carcassi; J Dausset
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

8.  A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group.

Authors:  M Fennessy; K Metcalfe; G A Hitman; M Niven; P A Biro; J Tuomilehto; E Tuomilehto-Wolf
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

9.  Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.

Authors:  J L Vicario; J Martinez-Laso; A Corell; J M Martin-Villa; P Morales; G Lledo; O G Segurado; D de Juan; A Arnaiz-Villena
Journal:  Diabetologia       Date:  1992-05       Impact factor: 10.122

10.  HLA genotype studies in juvenile insulin-dependent diabetes.

Authors:  I Deschamps; H Lestradet; C Bonaïti; M Schmid; M Busson; A Benajam; A Marcelli-Barge; J Hors
Journal:  Diabetologia       Date:  1980-09       Impact factor: 10.122
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