Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.

Literature DB >> 6813900

The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.

Abstract

7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly correlated to the serum level.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1982 PMID： 6813900 DOI： 10.1007/bf00432774

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

13 in total

1. Clinical significance of plasma chlorpromazine levels. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment.

Authors: T Kolakowska; D H Wiles; M G Gelder; A S McNeilly
Journal: Psychopharmacology (Berl) Date: 1976-08-26 Impact factor: 4.530

2. Effect of chlorpromazine and some of its metabolites on the accumulation of homovanilic acid in brain of mice.

Authors: J Dailey; G Sedvall; B Sjöquist
Journal: J Pharm Pharmacol Date: 1972-07 Impact factor: 3.765

3. The possible role of metabolites in therapeutic response to chlorpromazine treatment.

Authors: G Sakalis; T L Chan; S Gershon; S Park
Journal: Psychopharmacologia Date: 1973-09-28

4. Effect of chlorpromazine and some of its metabolites on synthesis and turnover of catecholamines formed from 14 C-tyrosine in mouse brain.

Authors: H Nybäck; G Sedvall
Journal: Psychopharmacologia Date: 1972

5. Correlation between plasma concentrations of chlorpromazine and clinical response.

Authors: L Rivera-Calimlim; T Gift; H A Nasrallah; R J Wyatt; L Lasagna
Journal: Commun Psychopharmacol Date: 1978

6. Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion.

Authors: G Alfredsson; F A Wiesel; P Skett
Journal: Psychopharmacology (Berl) Date: 1977-06-06 Impact factor: 4.530

7. Correlation between plasma chlorpromazine and its metabolites and clinical ratings in patients with acute relapse of schizophrenic and paranoid psychosis.

Authors: O T Phillipson; J M McKeown; J Baker; A F Healey
Journal: Br J Psychiatry Date: 1977-08 Impact factor: 9.319

8. A mass fragmentographic method for the determination of chlorpromazine and two of its active metabolites in human plasma and CSF.

Authors: G Alfredsson; B Wode-Helgodt; G Sedvall
Journal: Psychopharmacology (Berl) Date: 1976-07-28 Impact factor: 4.530

9. Clinical effects and drug concentrations in plasma and cerebrospinal fluid in psychotic patients treated with fixed doses of chlorpromazine.

Authors: B Wode-Helgodt; S Borg; B Fyrö; G Sedvall
Journal: Acta Psychiatr Scand Date: 1978-08 Impact factor: 6.392