| Literature DB >> 6813616 |
Abstract
A benzodiazepine antagonist, RO15-1788, was administered intragastrically to diazepam-dependent gastric fistula rats and a precipitated abstinence syndrome was observed. The intensity of the RO15-1788 precipitated abstinence syndrome, calculated by the Precipitated Abstinence Scale, increased in intensity in a log-dose manner over a dose range of 1.0 to 15.0 mg/kg of RO15-1788 and plateaued at the 15.0 mg/kg dose. The RO15-1788 precipitated diazepam abstinence syndrome differed both qualitatively and quantitatively from the diazepam withdrawal syndrome.Entities:
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Year: 1982 PMID： 6813616 DOI： 10.1016/0024-3205(82)90698-1
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037