| Literature DB >> 6813497 |
A P Intoccia, T L Flanagan, D T Walz, L Gutzait, J E Swagzdis, J Flagiello, B Y Hwang, R H Dewey, H Noguchi.
Abstract
Gold from orally administered auranofin (AF) was absorbed 17-23% in rats and 15-38% in dogs. Gold was highly bound to blood cells and plasma proteins. Gold terminal half life was 1.2-1.8 days in rat blood and plasma (measured for 7 days post dose) and 19.5 days in the dog (measured for 42 days). Excretion of gold (rat and dog) was via feces (84 and 81%) urine (10 and 16%) and bile (3% of dose). Rat tissue levels of gold were highest in the kidney. Evidence indicated that AF was rapidly degraded to triethylphosphine oxide with the remaining molecular fragments postulated to be a protein-gold complex and acetylthioglucose.Entities:
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Year: 1982 PMID： 6813497
Source DB: PubMed Journal: J Rheumatol Suppl ISSN： 0380-0903