| Literature DB >> 6812642 |
I Alam, A M Capitanio, J B Smith, K P Chepenik, R M Greene.
Abstract
High-performance liquid chromatography and radioimmunoassay were used to identify the prostaglandins synthesized by mouse embryo palate mesenchyme cells. Serum stimulated the release of several different metabolites of arachidonic acid including 6-ketoprostaglandin F1 alpha (the stable product of prostacyclin, prostaglandin I2), prostaglandin E2 and prostaglandin F2 alpha. Compared to control cells, the serum-stimulated cells produce elevated levels of prostaglandin E2 (36-fold), 6-ketoprostaglandin F1 alpha (15-fold) and prostaglandin F2 alpha (7-fold). The acetylenic analogue of arachidonic acid, 5,8,11,14-eicosatetraynoic acid prevented this accelerated synthesis.Entities:
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Year: 1982 PMID： 6812642 DOI： 10.1016/0005-2760(82)90360-5
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002