Literature DB >> 6812550

Mutagenicity tests with astemizole in vitro and in vivo.

P Vanparys, L Fabry, A Léonard, R Marsboom.   

Abstract

Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that is can be concluded that astemizole has no potential to induce chromosomal aberrations.

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Year:  1982        PMID： 6812550     DOI： 10.1007/bf00373399

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  11 in total

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Authors:  R G HAM
Journal:  Exp Cell Res       Date:  1963-02       Impact factor: 3.905

2.  Relationship between experimental results in mammals and man. I. Cytogenetic analysis of bone marrow injury induced by a single dose of cyclophosphamide.

Authors:  R Goetz; R J Srám; J Dohnalová
Journal:  Mutat Res       Date:  1975-08       Impact factor: 2.433

3.  New Giemsa method for the differential staining of sister chromatids.

Authors:  P Perry; S Wolff
Journal:  Nature       Date:  1974-09-13       Impact factor: 49.962

4.  Benzimidazolecarbamate methyl ester--evaluation of its effects in vivo and in vitro.

Authors:  J A Styles; R Garner
Journal:  Mutat Res       Date:  1974-06       Impact factor: 2.433

5.  Chemical induction of dominant lethals in female mice.

Authors:  W M Generoso
Journal:  Genetics       Date:  1969-02       Impact factor: 4.562

6.  The molecular mechanism of benzimidazole mutagenicity: in vitro studies on transcription and translation.

Authors:  J P Seiler
Journal:  Biochem Genet       Date:  1975-10       Impact factor: 1.890

7.  Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

Authors:  B N Ames; J Mccann; E Yamasaki
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433

8.  [The mutagenic effect of endoxan on the mouse].

Authors:  D Brittinger
Journal:  Humangenetik       Date:  1966

9.  The mutagenicity of benzimidazole and benzimidazole derivatives. VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster.

Authors:  J P Seiler
Journal:  Mutat Res       Date:  1976-11       Impact factor: 2.433

10.  Mutagenicity of aflatoxin B1: observations in vivo and their relation to in vitro activation.

Authors:  L Fabry; M Roberfroid
Journal:  Toxicol Lett       Date:  1981-01       Impact factor: 4.372
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  1 in total

Review 1.  Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.

Authors:  D M Richards; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-07       Impact factor: 9.546
  1 in total

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