Literature DB >> 6811964

Arachidonic acid and arachidonoyl-diglycerols increase in rat cerebrum during bicuculline-induced status epilepticus.

N G Bazan, S A Morelli de Liberti, E B Rodriguez de Turco.   

Abstract

Bicuculline-induced status epilepticus was found to be associated with increased amounts of free fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes.

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Year:  1982        PMID： 6811964     DOI： 10.1007/bf00965677

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  15 in total

1.  Cerebral metabolic changes during prolonged epileptic seizures in rats.

Authors:  A G Chapman; B S Meldrum; B K Siesjö
Journal:  J Neurochem       Date:  1977-05       Impact factor: 5.372

Review 2.  The role of prostaglandins in the central nervous system.

Authors:  L S Wolfe; F Coceani
Journal:  Annu Rev Physiol       Date:  1979       Impact factor: 19.318

3.  Lipid peroxidation in brain tissue in vitro: effects on phospholipids and fatty acids.

Authors:  E Westerberg; B Akesson; S Rehncrona; D S Smith; B K Siesjö
Journal:  Acta Physiol Scand       Date:  1979-04

4.  Positional distribution and turnover of fatty acids in phosphatidic acid, phosphinositides, phosphatidylcholine and phosphatidylethanolamine in rat brain in vivo.

Authors:  R R Baker; W Thompson
Journal:  Biochim Biophys Acta       Date:  1972-08-11

5.  Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia.

Authors:  N G Bazán
Journal:  J Neurochem       Date:  1971-08       Impact factor: 5.372

6.  Increased levels of brain free fatty acids after electroconvulsive shock.

Authors:  N G Bazan; H Rakowski
Journal:  Life Sci       Date:  1970-05-01       Impact factor: 5.037

7.  Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain.

Authors:  N G Bazán
Journal:  Biochim Biophys Acta       Date:  1970-10-06

8.  Free radicals in cerebral ischemia.

Authors:  E S Flamm; H B Demopoulos; M L Seligman; R G Poser; J Ransohoff
Journal:  Stroke       Date:  1978 Sep-Oct       Impact factor: 7.914

9.  Bicuculline and neuronal activity in motor cortex.

Authors:  J D Glass; G H Fromm; A S Chattha
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1980-01

10.  Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids.

Authors:  M D Majewska; J Strosznajder; J Lazarewicz
Journal:  Brain Res       Date:  1978-12-15       Impact factor: 3.252
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  9 in total

1.  Effect of various drugs producing convulsive seizures on rat brain glycerolipid metabolism.

Authors:  L Corazzi; G L Piccinin; R Roberti; N Marku; L Binaglia; G Porcellati; G Arienti
Journal:  Neurochem Res       Date:  1985-07       Impact factor: 3.996

2.  The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism.

Authors:  G Arienti; L Corazzi; G L Piccinin; R Roberti; L Binaglia; G Porcellati
Journal:  Ital J Neurol Sci       Date:  1984-06

3.  Long-chain acyl CoA synthetase in microsomes from rat brain gray matter and white matter.

Authors:  T S Reddy; N G Bazan
Journal:  Neurochem Res       Date:  1985-03       Impact factor: 3.996

4.  [3H]arachidonic acid metabolism in rat brain minces: effects of nucleotide triphosphates, CDPcholine and CMP.

Authors:  D S Damron; R V Dorman
Journal:  Neurochem Res       Date:  1988-08       Impact factor: 3.996

5.  Effect of subconvulsive doses of bicuculline on the incorporation of radioactive precursors into glycerolipids in rat brain areas.

Authors:  G Arienti; G L Piccinin; M T Ramacci; L Corazzi
Journal:  Ital J Neurol Sci       Date:  1989-06

6.  Cerebellar metabolism of phosphatidylethanolamine and its water-soluble precursors during bicuculline-induced convulsive seizures.

Authors:  N Marku; L Corazzi; G L Piccinin; G Arienti
Journal:  Neurochem Res       Date:  1987-04       Impact factor: 3.996

7.  Cerebellar metabolism of phosphatidylcholine and its hydrosoluble precursors during bicuculline-induced convulsive seizures.

Authors:  L Corazzi; G L Piccinin; N Marku; G Arienti
Journal:  Neurochem Res       Date:  1986-03       Impact factor: 3.996

8.  Reduced labeling of brain phosphatidylinositol, triacylglycerols, and diacylglycerols by [1-14C]arachidonic acid after electroconvulsive shock: potentiation of the effect by adrenergic drugs and comparison with palmitic acid labeling.

Authors:  M F Pediconi; E B Rodriguez de Turco; N G Bazan
Journal:  Neurochem Res       Date:  1986-02       Impact factor: 3.996

9.  Membrane lipid degradation is related to interictal cortical activity in a series of seizures.

Authors:  F Visioli; E B Rodriguez de Turco; N R Kreisman; N G Bazan
Journal:  Metab Brain Dis       Date:  1994-06       Impact factor: 3.584
  9 in total

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