Literature DB >> 6811958

Microsomal ethanol oxidation in the colonic mucosa of the rat. Effect of chronic ethanol ingestion.

H K Seitz, J Bösche, P Czygan, S Veith, B Kommerell.   

Abstract

A microsomal ethanol oxidizing system (MEOS) is present in the colonic mucosa of the rat. This MEOS metabolizes ethanol to acetaldehyde at the physiological pH of 7.4. Alcohol dehydrogenase or catalase are not involved in the reaction. The Michaelis Menten constant of the reaction is 13.7 +/- 0.3 mM and the maximal velocity is 219 +/- 30 pmoles acetaldehyde/mg microsomal protein X min. Bacterial ethanol metabolism does not contribute to the acetaldehyde production in the colonic MEOS. Chronic ethanol consumption has no effect on colonic MEOS activity. In addition, chronic ethanol ingestion does not affect colonic microsomal NADPH-cytochrome-c-reductase nor benzo(a) pyrene hydroxylase activity.

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Year:  1982        PMID： 6811958     DOI： 10.1007/bf00499078

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  24 in total

1.  Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat.

Authors:  E Barona; R C Pirola; C S Leiber
Journal:  Gastroenterology       Date:  1974-02       Impact factor: 22.682

2.  Ultrastructural changes in the small intestine induced by ethanol.

Authors:  E Rubin; B J Rybak; J Lindenbaum; C D Gerson; G Walker; C S Lieber
Journal:  Gastroenterology       Date:  1972-11       Impact factor: 22.682

3.  Quantitative relationship between amount of dietary fat and severity of alcoholic fatty liver.

Authors:  C S Lieber; L M DeCarli
Journal:  Am J Clin Nutr       Date:  1970-04       Impact factor: 7.045

4.  Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

Authors:  K Ohnishi; C S Lieber
Journal:  J Biol Chem       Date:  1977-10-25       Impact factor: 5.157

5.  Mucosal alcohol dehydrogenase- and aldehyde dehydrogenase-mediated ethanol oxidation in the digestive tract of the rat.

Authors:  Y Lamboeuf; G de Saint Blanquat; R Derache
Journal:  Biochem Pharmacol       Date:  1981-03-01       Impact factor: 5.858

6.  Characteristics of ethanol and acetaldehyde oxidation on flavin and pyridine nucleotide fluorescence changes in perfused rat liver.

Authors:  K O Lindros; N Oshino; R Parrilla; J R Williamson
Journal:  J Biol Chem       Date:  1974-12-25       Impact factor: 5.157

Review 7.  Ethanol metabolism and ethanol-drug interactions.

Authors:  E Mezey
Journal:  Biochem Pharmacol       Date:  1976-04-15       Impact factor: 5.858

8.  The photochemical action spectrum of the microsomal ethanol oxidizing system.

Authors:  T L Fabry; C S Lieber
Journal:  Alcohol Clin Exp Res       Date:  1979-07       Impact factor: 3.455

9.  Effect of bran and citrus pulp on hepatic, small intestinal and colonic HMG CoA reductase, cytochrome P450 and cytochrome b5 levels in rats.

Authors:  P A Smith-Barbaro; D Hanson; B S Reddy
Journal:  J Nutr       Date:  1981-05       Impact factor: 4.798

Review 10.  Colorectal cancer and beer drinking.

Authors:  J E Enstrom
Journal:  Br J Cancer       Date:  1977-05       Impact factor: 7.640
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  6 in total

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Authors:  Manuela G Neuman; Samuel W French; Barbara A French; Helmut K Seitz; Lawrence B Cohen; Sebastian Mueller; Natalia A Osna; Kusum K Kharbanda; Devanshi Seth; Abraham Bautista; Kyle J Thompson; Iain H McKillop; Irina A Kirpich; Craig J McClain; Ramon Bataller; Radu M Nanau; Mihai Voiculescu; Mihai Opris; Hong Shen; Brittany Tillman; Jun Li; Hui Liu; Paul G Thomes; Murali Ganesan; Steve Malnick
Journal:  Exp Mol Pathol       Date:  2014-09-11       Impact factor: 3.362

4.  Calcium Channels and Oxidative Stress Mediate a Synergistic Disruption of Tight Junctions by Ethanol and Acetaldehyde in Caco-2 Cell Monolayers.

Authors:  Geetha Samak; Ruchika Gangwar; Avtar S Meena; Roshan G Rao; Pradeep K Shukla; Bhargavi Manda; Damodaran Narayanan; Jonathan H Jaggar; RadhaKrishna Rao
Journal:  Sci Rep       Date:  2016-12-13       Impact factor: 4.379

Review 5.  Alcoholic Liver Disease: Current Mechanistic Aspects with Focus on Their Clinical Relevance.

Authors:  Rolf Teschke
Journal:  Biomedicines       Date:  2019-09-05

Review 6.  Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis.

Authors:  Caroline H Johnson; Jaya Prakash Golla; Evangelos Dioletis; Surendra Singh; Momoko Ishii; Georgia Charkoftaki; David C Thompson; Vasilis Vasiliou
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  6 in total

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