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Literature DB >> 6811900

Binding of aflatoxin B1, G1 and M to plasma albumin.

A Y Nassar, S E Megalla, H M El-Fattah, A H Hafez, T S El-Deap.

Abstract

The aflatoxins B1, G1 and their metabolites exist in the systemic blood as protein conjugate. This conjugation is specific to plasma albumin and proceeds enzymatically by liver and kidney cells. The aflatoxin-albumin conjugate is permanent and the conjugation is an irreversible one. This may interpret the acute liver damage of animal ingested a single dose of aflatoxin (3,4). The existence of bound aflatoxin-albumin in the systematic blood could be considered as one factor of low excretions of aflatoxins and their metabolites in urine (5,6,7).

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1982 PMID： 6811900 DOI： 10.1007/bf00636179

Source DB: PubMed Journal: Mycopathologia ISSN： 0301-486X Impact factor: 2.574

10 in total

1. MILK OF MAMMALS FED AN AFLATOXIN-CONTAINING DIET.

Authors: H DE IONGH; R O VLES
Journal: Nature Date: 1964-05-02 Impact factor: 49.962

2. Metabolism of aflatoxin in susceptible and resistant animal species.

Authors: D S Patterson; R Allcroft
Journal: Food Cosmet Toxicol Date: 1970-02

3. Aflatoxin M1 in human urine.

Authors: T C Campbell; J P Caedo; J Bulatao-Jayme; L Salamat; R W Engel
Journal: Nature Date: 1970-07-25 Impact factor: 49.962

4. Aflatoxin metabolism by liver microsomal preparations of two different species.

Authors: R S Portman; K M Plowman; T C Campbell
Journal: Biochem Biophys Res Commun Date: 1968-12-09 Impact factor: 3.575

5. Extraction of aflatoxin from rat liver.

Authors: W H Butler; J I Clifford
Journal: Nature Date: 1965-06-05 Impact factor: 49.962

Review 6. Mycotoxins: occurrence, chemistry, biological activity.

Authors: A Ciegler
Journal: Lloydia Date: 1975 Jan-Feb

7. Excretion and metabolism of orally administered aflatoxin B1 by rhesus monkeys.

Authors: J I Dalezios; D P Hsieh; G N Wogan
Journal: Food Cosmet Toxicol Date: 1973-08

8. Metabolism of aflatoxin in sheep: excretion of the "milk toxin".

Authors: R Allcroft; H Rogers; G Lewis; J Nabney; P E Best
Journal: Nature Date: 1966-01-08 Impact factor: 49.962

9. Aflatoxin and aflatoxicosis. I. Fungal flora of some food and animal feeds with special references to aflatoxin-producing abilities.

Authors: H M Abdel-Fattah; Y Y Kamel; S E Megalla; A H Hafez
Journal: Mycopathologia Date: 1982-03-19 Impact factor: 2.574

10. TOXIC EFFECTS OF GROUNDNUT MEAL CONTAINING AFLATOXIN TO RATS AND GUINEA-PIGS.

Authors: W H BUTLER; J M BARNES
Journal: Br J Cancer Date: 1963-12 Impact factor: 7.640