| Literature DB >> 6811886 |
W M Jongen, E G Harmsen, G M Alink, J H Koeman.
Abstract
The effect of mammalian metabolizing enzymes on the mutagenicity of dichloromethane was investigated in S. typhimurium strain TA100. The compound was directly mutagenic towards this strain, but the mutagenic activity was enhanced upon addition of either rat-liver microsomes or the cytosol fraction. Further experiments showed that both the cytochrome P450 oxygenases and the glutathione-S-transferases are involved in the bioactivation of dichloromethane.Entities:
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Year: 1982 PMID： 6811886 DOI： 10.1016/0027-5107(82)90256-1
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433