Literature DB >> 681084

Synthesis and opiate activity of human beta-endorphin analogs with various chain lengths.

H W Yeung, D Yamashiro, W C Chang, C H Li.   

Abstract

The synthesis of beta h-endorphin -(1--15), -(1--21), -(1--26), -(1--28) and -(1--29) have been accomplished by the solid-phase method. The opiate activities of the peptides were measured in the guinea pig ileum assay. Their relative potencies were beta h-endorphin (beta h-EP), 1.00; Met-enkephalin, 0.25: beta h-EP-(1--15), 0.17; beta H-EP-(1--21), 0.46; beta H-EP-(1-26), 0.48; beta h-EP-(1--28), 0.89; beta h-EP-(1--29), 1.04.

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Year:  1978        PMID: 681084     DOI: 10.1111/j.1399-3011.1978.tb02866.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN: 0367-8377


  2 in total

1.  Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.

Authors:  N M Lee; H J Friedman; L Leybin; T M Cho; H H Loh; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

2.  Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

Authors:  P Nicolas; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

  2 in total

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