Literature DB >> 6810769

Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.

E Jellum, E Munthe.   

Abstract

The excretory fate and plasma level of thiomalate were studied after intramuscular administration of auro-14C-thiomalate to 3 patients with rheumatoid arthritis. The gold and the thiomalate parts separated in vivo, and the free thiomalate was excreted in the urine, rapidly at first and then slowly. After one day about 60% of the 14C-label had been recovered in the urine. The plasma level also declined rapidly. The results are in complete agreement with those previously described in animal experiments.

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Year:  1982        PMID： 6810769      PMCID： PMC1000965          DOI： 10.1136/ard.41.4.431

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  2 in total

1.  Gold and thiol compounds in the treatment of rheumatoid arthritis: excretory fate and tissue distribution of thiomalate in relation to gold after administration of myocrisin (auro-thiomalate).

Authors:  E Jellum; E Munthe; G Guldal; J Aaseth
Journal:  Scand J Rheumatol Suppl       Date:  1979

2.  Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice.

Authors:  E Jellum; E Munthe; G Guldal; J Aaseth
Journal:  Ann Rheum Dis       Date:  1980-04       Impact factor: 19.103
  2 in total
  8 in total

1.  Binding of sodium aurothiomalate to human serum albumin in vitro at physiological conditions.

Authors:  S M Pedersen
Journal:  Ann Rheum Dis       Date:  1986-09       Impact factor: 19.103

2.  Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity.

Authors:  A E Koch; J C Burrows; P J Polverini; M Cho; S J Leibovich
Journal:  Agents Actions       Date:  1991-11

3.  Second-line anti-rheumatic drugs and free radical scavenging.

Authors:  H Strøm; I Ahnfelt-Rønne
Journal:  Agents Actions       Date:  1989-01

4.  Cultured human cells can acquire resistance to the antiproliferative effect of sodium aurothiomalate.

Authors:  A Glennås; H E Rugstad
Journal:  Ann Rheum Dis       Date:  1986-05       Impact factor: 19.103

5.  Cultured human cells with high levels of gold-binding cytosolic metallothionein are not resistant to the growth inhibitory effect of sodium aurothiomalate.

Authors:  A Glennås; H E Rugstad
Journal:  Ann Rheum Dis       Date:  1986-02       Impact factor: 19.103

6.  Progress in the characterization of gold drugs.

Authors:  M C Grootveld; M T Razi; P J Sadler
Journal:  Clin Rheumatol       Date:  1984-03       Impact factor: 2.980

7.  Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate.

Authors:  S R Rudge; D Perrett; A J Swannell
Journal:  Ann Rheum Dis       Date:  1984-02       Impact factor: 19.103

8.  Effect of gold sodium thiomalate and its thiomalate component on the in vitro expression of endothelial cell adhesion molecules.

Authors:  P M Newman; S S To; B G Robinson; V J Hyland; L Schrieber
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808
  8 in total

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