Literature DB >> 681076

The synthesis and opiate activity of human beta-endorphin analogs. Substituted at residue positions 27 and 31.

J Blake, L F Tseng, W C Chang, C H Li.   

Abstract

Four analogs of human beta-endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27-phenylalanine, 31-glycine]-betah-endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.

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Year:  1978        PMID： 681076     DOI： 10.1111/j.1399-3011.1978.tb02856.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  4 in total

1.  Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

Authors:  P Nicolas; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  beta-Endorphin: synthesis of analogs modified at the carboxyl terminus with increased activites.

Authors:  C H Li; D Yamashiro; L F Tseng; W C Chang; P Ferrara
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

3.  beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities.

Authors:  C H Li; D Yamashiro; L F Tseng; W C Chang; P Ferrara
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

4.  Beta-endorphin: replacement of tyrosine in position 27 by tryptophan increases analgesic potency--preparation and properties of the 2-nitrophenylsulfenyl derivative.

Authors:  C H Li; D Yamashiro; P Nicolas
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205
  4 in total

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