Human somatotropin. 55. Synthesis and growth-promoting activity of peptide analogs of the carboxyl terminal plasmin fragment.

Three analogs of the carboxyl terminal plasmin fragment of human somatotropin, [Nle 170, Ala165, 182, 189]-human somatotropin-(145-191), [Nle170, Ala165, 182, 189]-human somatotropin-(140-191), and [Lys135,136, 138, Glu137, 139, Nle170, Ala165, 182, 189]-human somatotropin-(135-191) have been synthesized by the solid-phase method. The synthetic peptides were assayed for growth-promoting activity and their potency was found to be comparable to that of [S-carbamideomethylcysteine165,182, 189]-human somatotropin-(141-191) which was derived from the native hormone.