The immunological response to polyvalent meningococcal vaccine in Bauchi State, Nigeria.

The post-vaccination antibody response to both Group A and Group C meningococcal polysaccharide antigen was studied in 397 male and 359 female vaccinated persons aged between 4 and 40 years from Bauchi Town and neighbouring villages in Nigeria. No difference in response was observed between the sexes. Highest antibody levels occurred in those aged between 13 and 28 years. Haemoglobin genotype did not affect response. Malnourished children had significantly lower mean IgG, IgA and IgM levels and the response to meningovaccine was also lower than in normal children.