Aspergillus osteomyelitis in an immunocompetent adolescent: a case report and review of the literature.

A black male adolescent with intact cellular and humoral immunity developed Aspergillus flavus-caused osteomyelitis involving the right tibial epiphysis following penetrating injury to that area. There was an apparent cure following amphotericin B therapy for six weeks. The clinical, pathologic, and therapeutic features of this case are described and compared with those in previously published cases. This case report represents the first well documented case of Aspergillus osteomyelitis in an immunocompetent host. The increasing incidence of invasive disease due to Aspergillus species and the increased awareness of the incidence of mycotic bone infections, particularly in pediatric patients, may allow further definition of pathogenesis and appropriate therapy.