Literature DB >> 6809288

Use of osmotic minipumps for delivery of parathyroid hormone.

J M Hock, H A Simmons, M C Schiess, L G Raisz.   

Abstract

To determine if osmotic minipumps can be used for the local delivery of parathyroid hormone (PTH), we examined the bone resorbing activity of PTH in minipumps, either removed and assayed in bone organ cultures or released over rat calvaria. Biological activity of PTH was maintained for up to 6 days when the hormone solution contained serum and the minipumps and tubing were siliconized and flushed with diluent prior to use. Addition of cysteine did not enhance activity.

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Year:  1982        PMID： 6809288     DOI： 10.1007/BF02411249

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  5 in total

1.  Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations.

Authors:  F Theeuwes; S I Yum
Journal:  Ann Biomed Eng       Date:  1976-12       Impact factor: 3.934

2.  Cortisol secretion during intrapituitary infusion of angiotensin II in conscious dogs.

Authors:  J W Maran; F E Yates
Journal:  Am J Physiol       Date:  1977-10

3.  Loss of calcemic effects of calcitonin and parathyroid hormone infused continuously into rats using the Alzet osmotic minipump.

Authors:  J F Obie; C W Cooper
Journal:  J Pharmacol Exp Ther       Date:  1979-06       Impact factor: 4.030

4.  Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture.

Authors:  L G Raisz; I Niemann
Journal:  Endocrinology       Date:  1969-09       Impact factor: 4.736

5.  Comparison of the effects of a potent synthetic analog of bovine parathyroid hormone with native bPTH-(1-84) and synthetic bPTH-(1-34) on bone resorption and collagen synthesis.

Authors:  L G Raisz; J Lorenzo; S Gworek; B Kream; M Rosenblatt
Journal:  Calcif Tissue Int       Date:  1979       Impact factor: 4.333
  5 in total
  1 in total

1.  Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.

Authors:  A J Yates; G E Gutierrez; P Smolens; P S Travis; M S Katz; T B Aufdemorte; B F Boyce; T K Hymer; J W Poser; G R Mundy
Journal:  J Clin Invest       Date:  1988-03       Impact factor: 14.808
  1 in total

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