Literature DB >> 6809025

The effects of ampicillin on oral contraceptive steroids in women.

D J Back, A M Breckenridge, M MacIver, M Orme, P H Rowe, C Staiger, E Thomas, J Tjia.   

Abstract

1 Thirteen women taking long term oral contraceptive steroids were studied while taking ampicillin (500 mg three times daily) and compared to a control cycle while not taking ampicillin. 2 There were no significant changes in the plasma concentrations of ethinyloestradiol, levonorgestrel, follicle stimulating hormone or progesterone, although lower concentrations of ethinyloestradiol were noted in two women. 3 We conclude that most patients taking oral contraceptive steroids do not need to take alternative contraceptive precautions while taking ampicillin.

Entities:  

Keywords:  Biology; Contraception; Contraceptive Agents, Estrogen--analysis; Contraceptive Agents, Female--analysis; Contraceptive Agents, Progestin--analysis; Contraceptive Agents--analysis; Control Groups; Endocrine System; Estrogens; Ethinyl Estradiol--analysis; Family Planning; Follicle Stimulating Hormone--analysis; Gonadotropins; Gonadotropins, Pituitary; Hormones; Levonorgestrel--analysis; Norethindrone Acetate; Physiology; Pregnancy, Unplanned; Progestational Hormones; Progesterone--analysis; Reproductive Control Agents; Research Methodology

Mesh:

Substances:

Year:  1982        PMID: 6809025      PMCID: PMC1427567          DOI: 10.1111/j.1365-2125.1982.tb04932.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  17 in total

1.  [Enzyme induction by drugs and hormonal contraception].

Authors:  E Hempel; W Böhm; W Carol; G Klinger
Journal:  Zentralbl Gynakol       Date:  1973-10-12

2.  Single luteal phase serum progesterone assay as an indicator of ovulation.

Authors:  R Israel; D R Mishell; S C Stone; I H Thorneycroft; D L Moyer
Journal:  Am J Obstet Gynecol       Date:  1972-04-15       Impact factor: 8.661

3.  Fate of ingested radiolabeled ethynylestradiol and its 3-cyclopentyl ether in patients with bile fistulas.

Authors:  D I Cargill; B G Steinetz; E Gosnell; V L Beach; A Meli; G I Fujimoto; B M Reynolds
Journal:  J Clin Endocrinol Metab       Date:  1969-08       Impact factor: 5.958

4.  Kinetics of norethindrone in women. I. Radioimmunoassay and concentrations during multiple dosing.

Authors:  D J Back; A M Breckenridge; F E Crawford; M Mciver; M L Orme; B K Park; P H Rowe; E Smith
Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

5.  The effect of antibiotics on the enterohepatic circulation of ethinylestradiol and norethisterone in the rat.

Authors:  D J Back; A M Breckenridge; M Challiner; F E Crawford; M L Orme; P H Rowe; E Smith
Journal:  J Steroid Biochem       Date:  1978-06       Impact factor: 4.292

6.  Intestinal bacteria and the hydrolysis of glycosidic bonds.

Authors:  G Hawksworth; B S Drasar; M J Hill
Journal:  J Med Microbiol       Date:  1971-11       Impact factor: 2.472

7.  The effect of rifampicin on norethisterone pharmacokinetics.

Authors:  D J Back; A M Breckenridge; F Crawford; M MacIver; M L Orme; B K Park; P H Rowe; E Smith
Journal:  Eur J Clin Pharmacol       Date:  1979-04-17       Impact factor: 2.953

8.  Talampicillin: a new derivative of ampicillin.

Authors:  D A Leigh; D S Reeves; K Simmons; A L Thomas; P J Wilkinson
Journal:  Br Med J       Date:  1976-06-05

9.  An investigation of the pharmacokinetics of ethynylestradiol in women using radioimmunoassay.

Authors:  D J Back; A M Breckenridge; F E Crawford; M MacIver; M L Orme; P H Rowe; M J Watts
Journal:  Contraception       Date:  1979-09       Impact factor: 3.375

10.  Radioimmunosorbent assay of follicle-stimulating hormone and luteinizing hormone in serum and urine from men and women.

Authors:  L Wide; S J Nillius; C Gemzell; P Roos
Journal:  Acta Endocrinol Suppl (Copenh)       Date:  1973
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  7 in total

Review 1.  Pharmacokinetic drug interactions with oral contraceptives.

Authors:  D J Back; M L Orme
Journal:  Clin Pharmacokinet       Date:  1990-06       Impact factor: 6.447

2.  Evaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anticonvulsants and antibiotics.

Authors:  D J Back; S F Grimmer; M L Orme; C Proudlove; R D Mann; A M Breckenridge
Journal:  Br J Clin Pharmacol       Date:  1988-05       Impact factor: 4.335

3.  Antibiotic and oral contraceptive drug interactions: Is there a need for concern?

Authors:  G G Zhanel; S Siemens; K Slayter; L Mandell
Journal:  Can J Infect Dis       Date:  1999-11

Review 4.  Clinical pharmacokinetics of oral contraceptive steroids.

Authors:  M L Orme; D J Back; A M Breckenridge
Journal:  Clin Pharmacokinet       Date:  1983 Mar-Apr       Impact factor: 6.447

Review 5.  The third S.K. & F. Prize lecture, University of London, December 1981. The clinical pharmacology of oral contraceptive steroids.

Authors:  M L Orme
Journal:  Br J Clin Pharmacol       Date:  1982-07       Impact factor: 4.335

Review 6.  Interactions between oral contraceptives and antifungals/antibacterials. Is contraceptive failure the result?

Authors:  E Weisberg
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

Review 7.  Oral contraceptives. Are drug interactions of clinical significance?

Authors:  G M Shenfield
Journal:  Drug Saf       Date:  1993-07       Impact factor: 5.606

  7 in total

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