Literature DB >> 6808510

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

G G Poirier, G de Murcia, J Jongstra-Bilen, C Niedergang, P Mandel.   

Abstract

When rat pancreatic polynucleosomes were poly(ADP-ribosyl)ated with purified calf thymus poly(ADP-ribose) polymerase and examined by electron microscopy, a relaxation of their native zigzag structure was observed. At high ionic strengths control nucleosomes condensed into 250-A-thick fibers, but poly(ADP-ribosyl)ated polynucleosomes did not; they showed a close resemblance to chromatin depleted of histone H1. The relaxed state of poly(ADP-ribosyl)ated polynucleosomes was also confirmed by sedimentation velocity analysis. Histone H1 was found to be the major histone acceptor of poly(ADP-ribose). Poly(ADP-ribose) linked to histone H1 did not seem to cause its dissociation from the chromatin, but it impaired significantly its effect on chromatin condensation.

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Year:  1982        PMID： 6808510      PMCID： PMC346432          DOI： 10.1073/pnas.79.11.3423

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Nuclear protein modification and chromatin substructure. 2. Internucleosomal localization of poly(adenosine diphosphate-ribose) polymerase.

Authors:  C P Giri; M H West; M L Ramirez; M Smulson
Journal:  Biochemistry       Date:  1978-08-22       Impact factor: 3.162

2.  A nuclear protein-modifying enzyme is responsive to ordered chromatin structure.

Authors:  T R Butt; J F Brothers; C P Giri; M E Smulson
Journal:  Nucleic Acids Res       Date:  1978-08       Impact factor: 16.971

3.  Nuclear protein modification and chromatin substructure. 1. Differential poly(adenosine diphosphate) ribosylation of chromosomal proteins in nuclei versus isolated nucleosomes.

Authors:  C P Giri; M H West; M Smulson
Journal:  Biochemistry       Date:  1978-08-22       Impact factor: 3.162

4.  Purification and properties of calf thymus poly adenosine diphosphate ribose polymerase.

Authors:  P Mandel; H Okazaki; C Niedergang
Journal:  FEBS Lett       Date:  1977-12-15       Impact factor: 4.124

5.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

6.  Structure of chromatin containing extensively acetylated H3 and H4.

Authors:  R T Simpson
Journal:  Cell       Date:  1978-04       Impact factor: 41.582

7.  Nuclear protein modification and chromatin substructure. 3. Relationship between poly(adenosine diphosphate) ribosylation and different functional forms of chromatin.

Authors:  D B Jump; T R Butt; M Smulson
Journal:  Biochemistry       Date:  1979-03-20       Impact factor: 3.162

8.  Effect of histone acetylation on structure and in vitro transcription of chromatin.

Authors:  D J Mathis; P Oudet; B Wasylyk; P Chambon
Journal:  Nucleic Acids Res       Date:  1978-10       Impact factor: 16.971

9.  Properties of the complex between histone H1 and poly(ADP-ribose synthesised in HeLa cell nuclei.

Authors:  P R Stone; W S Lorimer; W R Kidwell
Journal:  Eur J Biochem       Date:  1977-11-15

10.  Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

Authors:  F Thoma; T Koller; A Klug
Journal:  J Cell Biol       Date:  1979-11       Impact factor: 10.539
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  151 in total

1.  A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.

Authors:  S Vispe; T M Yung; J Ritchot; H Serizawa; M S Satoh
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

2.  Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity.

Authors:  Orlando Huambachano; Fatima Herrera; Ann Rancourt; Masahiko S Satoh
Journal:  J Biol Chem       Date:  2010-12-23       Impact factor: 5.157

Review 3.  ADP-ribosyltransferases and poly ADP-ribosylation.

Authors:  Chao Liu; Xiaochun Yu
Journal:  Curr Protein Pept Sci       Date:  2015       Impact factor: 3.272

Review 4.  Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair.

Authors:  Lok Ming Tam; Nathan E Price; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2020-02-07       Impact factor: 3.739

5.  PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.

Authors:  Nadine Martin; Klaus Schwamborn; Valérie Schreiber; Andreas Werner; Christelle Guillier; Xiang-Dong Zhang; Oliver Bischof; Jacob-S Seeler; Anne Dejean
Journal:  EMBO J       Date:  2009-09-24       Impact factor: 11.598

Review 6.  Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

Authors:  D D'Amours; S Desnoyers; I D'Silva; G G Poirier
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

7.  Co-operative interactions of oligonucleosomal DNA with the H1e histone variant and its poly(ADP-ribosyl)ated isoform.

Authors:  M D'erme; G Zardo; A Reale; P Caiafa
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857

Review 8.  PARP inhibition: PARP1 and beyond.

Authors:  Michèle Rouleau; Anand Patel; Michael J Hendzel; Scott H Kaufmann; Guy G Poirier
Journal:  Nat Rev Cancer       Date:  2010-03-04       Impact factor: 60.716

Review 9.  Mitochondrial and nuclear cross talk in cell death: parthanatos.

Authors:  Shaida A Andrabi; Ted M Dawson; Valina L Dawson
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691

Review 10.  Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation.

Authors:  W Lee Kraus
Journal:  Curr Opin Cell Biol       Date:  2008-04-29       Impact factor: 8.382
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