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Literature DB >> 6807969

The process of dissolving apolipoprotein A-I in an aqueous buffer.

Abstract

Human plasma apolipoprotein A-I (apoA-I) has been studied in an aqueous solution by the techniques of high performance liquid chromatography (HPLC), circular dichroic spectroscopy, and sedimentation equilibrium ultracentrifugation. The results indicate that an oligomer is formed as an intermediate step of dissolving lysophilized apoA-I. The process of further dissolution of this oligomer is an irreversible, temperature-dependent dissociation. The half-life of this intermediate oligomer is 3 min at 37 degrees C and 80 h at 30 degrees C. The completely dissolved apoA-I in an aqueous buffer self-associates with conformational alteration. The self-association equilibrium is too rapid to be demonstrated by HPLC.

Entities: Gene Species

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Year: 1982 PMID： 6807969 DOI： 10.1093/oxfordjournals.jbchem.a133811

Source DB: PubMed Journal: J Biochem ISSN： 0021-924X Impact factor: 3.387

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Cited

12 in total

Review 1. Three-dimensional models of HDL apoA-I: implications for its assembly and function.

Authors: Michael J Thomas; Shaila Bhat; Mary G Sorci-Thomas
Journal: J Lipid Res Date: 2008-05-30 Impact factor: 5.922

2. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Authors: Nobukiyo Tanaka; Sumiko Abe-Dohmae; Noriyuki Iwamoto; Michael L Fitzgerald; Shinji Yokoyama
Journal: Atherosclerosis Date: 2011-06-23 Impact factor: 5.162

3. Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices.

Authors: Mary G Sorci-Thomas; Shaila Bhat; Michael J Thomas
Journal: Clin Lipidol Date: 2009-02

4. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

Authors: Nobukiyo Tanaka; Sumiko Abe-Dohmae; Noriyuki Iwamoto; Michael L Fitzgerald; Shinji Yokoyama
Journal: J Lipid Res Date: 2010-05-22 Impact factor: 5.922

5. Methods for Monitoring ABCA1-Dependent Sterol Release.

Authors: Yoshio Yamauchi; Shinji Yokoyama; Ta-Yuan Chang
Journal: Methods Mol Biol Date: 2017

6. A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration.

Authors: Akiko Tsunemi; Takahiro Ueno; Noboru Fukuda; Takayoshi Watanabe; Kazunobu Tahira; Akira Haketa; Yoshinari Hatanaka; Sho Tanaka; Taro Matsumoto; Yoshiaki Matsumoto; Hiroki Nagase; Masayoshi Soma
Journal: J Mol Med (Berl) Date: 2014-01-25 Impact factor: 4.599

The process of dissolving apolipoprotein A-I in an aqueous buffer.

Review 1. Three-dimensional models of HDL apoA-I: implications for its assembly and function.

2. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

3. Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices.

4. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

5. Methods for Monitoring ABCA1-Dependent Sterol Release.

6. A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration.

7. Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.

8. Multiple forms of sheep serum A-esterase activity associated with the high-density lipoprotein.

9. Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice.

10. ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis.