Literature DB >> 680793

Cyclophosphamide-like cellular immunostimulation induced by 6-thioguanine (Lanvis).

H Van Dijk, G A Voermans.   

Abstract

The possible immunostimulating effect of 6-thioguanine was studied in the mouse. It caused a dose-dependent suppression of the cellular and humoral immune response if administered 1 day before immunization. If, however, the interval between 6-thioguanine administration and immunization was extended to 5 days, a significant enhancement of delayed hypersensitivity was observed. The The enhancement occurred only after immunization with 10(6) and 10(7) sheep red cells. The analogy between the immunostimulating effects of 6-thioguanine and cyclophosphamide is discussed.

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Year:  1978        PMID： 680793      PMCID： PMC1457422     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  17 in total

1.  Stimulation of the immune response against SRBC by reduction of corticosterone plasma levels: mediation by mononuclear phagocytes.

Authors:  H Van Dijk; J Testerink; E Noordegraaf
Journal:  Cell Immunol       Date:  1976-07       Impact factor: 4.868

2.  Effects of variation in time and dose of cyclophosphamide injection on delayed hypersensitivity and antibody formation.

Authors:  J A Kerckhaert; F M Hofhuis; J M Willers
Journal:  Cell Immunol       Date:  1977-03-15       Impact factor: 4.868

3.  Influence of cyclophosphamide on the delayed hypersensitivity of the mouse.

Authors:  J A Kerckhaert; G J Van den Berg; J M Willers
Journal:  Ann Immunol (Paris)       Date:  1974 Mar-Apr

4.  B-cell suppression of delayed hypersensitivity reactions.

Authors:  S I Katz; D Parker; J L Turk
Journal:  Nature       Date:  1974-10-11       Impact factor: 49.962

5.  Influence of cyclophosphamide on the delayed hypersensitivity in the mouse after intraperitoneal immunization.

Authors:  J A Kerckhaert
Journal:  Ann Immunol (Paris)       Date:  1974-06

6.  Use of normal mouse serum to detect indirect plaque-forming cells.

Authors:  D M Silver; H J Winn
Journal:  J Immunol       Date:  1973-10       Impact factor: 5.422

Review 7.  Immunosuppressive drugs.

Authors:  T Makinodan; G W Santos; R P Quinn
Journal:  Pharmacol Rev       Date:  1970-06       Impact factor: 25.468

8.  A semi-electronic device for measuring delayed hypersensitivity in the mouse by footpad swelling.

Authors:  H Van Dijk; H Versteeg; H J Hennink
Journal:  J Immunol Methods       Date:  1976       Impact factor: 2.303

Review 9.  How corticosteroids work.

Authors:  H N Claman
Journal:  J Allergy Clin Immunol       Date:  1975-03       Impact factor: 10.793

10.  Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.

Authors:  P H Lagrange; G B Mackaness; T E Miller
Journal:  J Exp Med       Date:  1974-06-01       Impact factor: 14.307
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  1 in total

1.  Enhancement of delayed hypersensitivity reaction with varieties of anti-cancer drugs. A common biological phenomenon.

Authors:  M Goto; A Mitsuoka; M Sugiyama; M Kitano
Journal:  J Exp Med       Date:  1981-07-01       Impact factor: 14.307
  1 in total

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