Literature DB >> 6805469

Monensin inhibits synthesis of proteoglycan, but not of hyaluronate, in chondrocytes.

D Mitchell, T Hardingham.   

Abstract

Monensin (10nm-1mum) inhibited the incorporation of [(35)S]sulphate and [(3)H]glucosamine into proteoglycans by rat chondrosarcoma cells, but the incorporation of [(3)H]glucosamine into hyaluronate was unaffected. The results suggest that hyaluronate synthesis occurs in a cell compartment separate from chondroitin sulphate synthesis.

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Year:  1982        PMID： 6805469      PMCID： PMC1158098          DOI： 10.1042/bj2020249

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

Review 1.  Intracellular aspects of the process of protein synthesis.

Authors:  G Palade
Journal:  Science       Date:  1975-08-01       Impact factor: 47.728

2.  Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts.

Authors:  N Uchida; H Smilowitz; M L Tanzer
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

3.  Undersulfated proteoglycans are secreted by cultured chondrocytes in the presence of the ionophore monensin.

Authors:  K Tajiri; N Uchida; M L Tanzer
Journal:  J Biol Chem       Date:  1980-07-10       Impact factor: 5.157

4.  Proteoglycans: their structure, interactions and molecular organization in cartilage.

Authors:  T Hardingham
Journal:  Biochem Soc Trans       Date:  1981-12       Impact factor: 5.407

5.  Identification of core protein, an intermediate in proteoglycan biosynthesis in cultured chondrocytes from the Swarm rat chondrosarcoma.

Authors:  J H Kimura; E J Thonar; V C Hascall; A Reiner; A R Poole
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

6.  Hyaluronate-proteoglycan complex: evidence for separate biosynthesis mechanisms of the macromolecules.

Authors:  T O Kleine
Journal:  Connect Tissue Res       Date:  1978       Impact factor: 3.417

7.  Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma.

Authors:  J H Kimura; T E Hardingham; V C Hascall; M Solursh
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

8.  Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein.

Authors:  N B Schwartz
Journal:  J Biol Chem       Date:  1977-09-25       Impact factor: 5.157

9.  Plasma cell immunoglobulin secretion: arrest is accompanied by alterations of the golgi complex.

Authors:  A M Tartakoff; P Vassalli
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

10.  Comparative studies of intracellular transport of secretory proteins.

Authors:  A Tartakoff; P Vassalli; M Détraz
Journal:  J Cell Biol       Date:  1978-12       Impact factor: 10.539
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  11 in total

1.  Monensin inhibits the first cellular movements in early chick embryo.

Authors:  Nikolas Zagris; Maria Panagopoulou
Journal:  Rouxs Arch Dev Biol       Date:  1991-06

2.  Ultrastructural demonstration of lectin binding sites in the Golgi apparatus of rat epiphyseal chondrocytes.

Authors:  A Velasco; J Hidalgo; M Müller; G Garcia-Herdugo
Journal:  Histochemistry       Date:  1988

3.  Subcellular localization of the sulphation reaction of heparan sulphate synthesis and transport of the proteoglycan to the cell surface in rat liver.

Authors:  J M Graham; D J Winterbourne
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

4.  Proteoglycan aggregate formation by articular chondrocytes. Decrease in link-protein synthesis during culture.

Authors:  A H Plaas; J D Sandy; H Muir
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857

5.  Inhibition of hyaluronate synthesis.

Authors:  P Prehm
Journal:  Biochem J       Date:  1985-02-01       Impact factor: 3.857

6.  The secretion of tropoelastin by chick-embryo artery cells.

Authors:  N A Saunders; M E Grant
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

7.  Hyaluronate is synthesized at plasma membranes.

Authors:  P Prehm
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

8.  Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure.

Authors:  M J Lammi; R Inkinen; J J Parkkinen; T Häkkinen; M Jortikka; L O Nelimarkka; H T Järveläinen; M I Tammi
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857

Review 9.  Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.

Authors:  H H Mollenhauer; D J Morré; L D Rowe
Journal:  Biochim Biophys Acta       Date:  1990-05-07

10.  Proteoglycan biosynthesis in chondrocytes: protein A-gold localization of proteoglycan protein core and chondroitin sulfate within Golgi subcompartments.

Authors:  A Ratcliffe; P R Fryer; T E Hardingham
Journal:  J Cell Biol       Date:  1985-12       Impact factor: 10.539
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