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Literature DB >> 6805263

Histamine-stimulated prostaglandin synthesis in rat brain microvessels.

E Dux, F Joó, A Gecse, Z Mezei, L Dux, J Hideg, G Telegdy.

Abstract

The histamine-sensitivity of prostacyclin and prostaglandin synthesis was investigated in isolated brain microvessels prepared from normal and hypoxic exercised rats. 10(-4) M histamine stimulated the in vitro synthesis of all components of arachidonate cascade. The chronic hypoxic exercise also resulted in an enhanced production of each fraction. Hypoxia and histamine showed an additive effect in the synthesis of PGE2 only. The possible molecular mechanism induced by hypoxia and histamine is discussed.

Entities: Chemical Disease Species

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Year: 1982 PMID： 6805263 DOI： 10.1007/BF01965127

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

9 in total

1. A procedure for the isolation of capillaries from rat brain.

Authors: F Joó; I Karnushina
Journal: Cytobios Date: 1973 Sep-Oct

2. Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other agonists.

Authors: M Huang; G I Drummond
Journal: Mol Pharmacol Date: 1979-09 Impact factor: 4.436

3. Studies on a capillary-rich fraction isolated from brain: histaminic components and characterization of the histamine receptors linked to adenylate cyclase.

Authors: I L Karnushina; J M Palacios; G Barbin; E Dux; F Joó; J C Schwartz
Journal: J Neurochem Date: 1980-05 Impact factor: 5.372

1 in total

1. Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine.

Authors: S D Bamforth; S L Lightman; J Greenwood
Journal: Am J Pathol Date: 1997-01 Impact factor: 4.307

1 in total

Histamine-stimulated prostaglandin synthesis in rat brain microvessels.

1. A procedure for the isolation of capillaries from rat brain.

2. Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other agonists.

3. Studies on a capillary-rich fraction isolated from brain: histaminic components and characterization of the histamine receptors linked to adenylate cyclase.

4. The effect of hypoxic and hypobaric exercises on the blood-brain barrier in rats.

5. Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides.

6. Prostaglandin endoperoxide metabolism by bovine cerebral microvessels.

7. Histamine in brain capillaries.

8. Prostacyclin and prostaglandin synthesis in rat brain microvessels: characteristic changes in hypoxaemia.

9. The synthesis of prostaglandins by bovine cerebral microvessels.

1. Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine.