Literature DB >> 6804255

The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.

P A Barrett, E Beveridge, D Bull, I C Caldwell, P J Islip, R A Neal, N C Woods.   

Abstract

The biological properties of a novel compound 353C with high activity against Trypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C has a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals.

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Year:  1982        PMID： 6804255     DOI： 10.1007/BF01949378

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  2 in total

1.  Selective primary health care: an interim strategy for disease control in developing countries.

Authors:  J A Walsh; K S Warren
Journal:  N Engl J Med       Date:  1979-11-01       Impact factor: 91.245

2.  The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).

Authors:  E Beveridge; I C Caldwell; V S Latter; R A Neal; V Udall; M M Waldron
Journal:  Trans R Soc Trop Med Hyg       Date:  1980       Impact factor: 2.184
  2 in total
  1 in total

1.  Trypanocidal activity of 2-propen-1-amine derivatives on trypomastigotes culture and in animal model.

Authors:  D A Oliveira; D G Pereira; A M A P Fernandes; S L De Castro; A R M Souza Brito; A O De Souza; N Durán
Journal:  Parasitol Res       Date:  2004-12-23       Impact factor: 2.289
  1 in total

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