Literature DB >> 6804104

Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).

J L Au, W Sadée.   

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Year:  1981        PMID： 6804104     DOI： 10.1007/BF00258214

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


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  19 in total

1.  In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil.

Authors:  J P Horwitz; J J McCormick; K D Philips; V M Maher; J R Otto; D Kessel; J Zemlicka
Journal:  Cancer Res       Date:  1975-05       Impact factor: 12.701

2.  Identification and comparative analysis of thymidine phosphorylase in the plasma of healthy subjects and cancer patients.

Authors:  J L Pauly; M G Schuller; A A Zelcer; T A Kirss; S S Gore; M J Germain
Journal:  J Natl Cancer Inst       Date:  1977-06       Impact factor: 13.506

3.  To biological activity of antitumour antimetabolite "ftorafur".

Authors:  A Z Smolyanskaya; O A Tugarinov
Journal:  Neoplasma       Date:  1972       Impact factor: 2.575

4.  Structure of two hydroxylated metabolites of ftorafur.

Authors:  R B Meyer; C H Levenson
Journal:  Biochem Pharmacol       Date:  1980-02-15       Impact factor: 5.858

5.  Effect of N1-(2'-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on nucleic acid and protein biosyntheses in Ehrlich ascites cells.

Authors:  S Fujimoto; T Akao; B Itoh; I Koshizuka; K Koyano
Journal:  Cancer Res       Date:  1976-01       Impact factor: 12.701

6.  Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.

Authors:  J A Benvenuto; K Lu; S W Hall; R S Benjamin; T L Loo
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

7.  Comparison of 5-fluorouracil and ftorafur. I. Quantitative and qualitative differences in toxicity to mice.

Authors:  R K Johnson; B T Garibjanian; D P Houchens; I Kline; M R Gaston; A B Syrkin; A Goldin
Journal:  Cancer Treat Rep       Date:  1976-09

8.  Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-k-fluorouracil into the R and S isomers and examination of the biological activities of the isomers.

Authors:  M Yasumoto; A Moriyama; N Unemi; S Hashimoto; T Suzue
Journal:  J Med Chem       Date:  1977-12       Impact factor: 7.446

9.  Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-hydroxyftorafur.

Authors:  A J Lin; R S Benjamin; P N Rao; T L Loo
Journal:  J Med Chem       Date:  1979-09       Impact factor: 7.446

10.  Identification of metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) formed in vitro by rat liver microsomes.

Authors:  T Marunaka; Y Minami; Y Umeno; A Yasuda; T Sato; S Fujii
Journal:  Chem Pharm Bull (Tokyo)       Date:  1980-06       Impact factor: 1.645
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  1 in total

1.  Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.

Authors:  Ikuo Yamamiya; Kunihiro Yoshisue; Yuji Ishii; Hideyuki Yamada; Ken-Ichiro Yoshida
Journal:  Pharmacol Res Perspect       Date:  2013-10-23
  1 in total

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