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Literature DB >> 6802745

Bovine immune response to Theileria parva: neutralizing antibodies to sporozoites.

A J Musoke, V M Nantulya, G Buscher, R A Masake, B Otim.

Abstract

The role of antibodies in the neutralization of sporozoites of Theileria parva was investigated. It was found that serum obtained from cattle recovered from East Coast fever (ECF) and rabbits immunized with sporozoites was capable of neutralizing the parasites. The serum was then fractionated by gel filtration and anion exchange chromatography to identify which antibody class or subclass was responsible for the neutralization. In bovine hyperimmune serum the neutralizing capacity was in the fraction containing IgG2 immunoglobulins. In rabbit anti-sporozoite serum the neutralizing capacity also resided in the IgG2 containing fraction. These results suggest that humoral antibodies may play a role in resistance to reinfection with T. parva. A mechanism for this acquired resistance is proposed based upon the recently established biological properties of bovine IgG2 immunoglobulins.

Entities: Disease Species

Mesh：

Substances：

Year: 1982 PMID： 6802745 PMCID： PMC1555427

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

13 in total

1. Evidence for reappearance of Trypanosoma brucei variable antigen types in relapse populations.

Authors: V M Nantulya; A J Musoke; A F Barbet; G E Roelants
Journal: J Parasitol Date: 1979-10 Impact factor: 1.276

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Authors: J R Allen; H M Khalil; J E Graham
Journal: Immunology Date: 1979-11 Impact factor: 7.397

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Authors: M J Burridge
Journal: Res Vet Sci Date: 1971-07 Impact factor: 2.534

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Authors: D L Emery; W I Morrison
Journal: Immunology Date: 1980-06 Impact factor: 7.397

5. Crossreacting determinants in variant-specific surface antigens of African trypanosomes.

Authors: A F Barbet; T C McGuire
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

6. The immunological response of the rat to infection with Taenia taeniaeformis. I. Immunoglobulin classes involved in passive transfer of resistance.

Authors: R W Leid; J F Williams
Journal: Immunology Date: 1974-08 Impact factor: 7.397

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Authors: S I Muhammed; G G Wagner; L H Lauerman
Journal: Immunology Date: 1974-12 Impact factor: 7.397

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Journal: Scand J Immunol Date: 1978 Impact factor: 3.487

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Authors: S I Muhammed; L H Lauerman; L W Johnson
Journal: Am J Vet Res Date: 1975-04 Impact factor: 1.156

10. Functional properties of bovine IgG1 and IgG2: interaction with complement, macrophages, neutrophils and skin.

Authors: T C McGuire; A J Musoke; T Kurtti
Journal: Immunology Date: 1979-10 Impact factor: 7.397

15 in total

1. Stage-specific responses following infection with Theileria annulata as evaluated using ELISA.

Authors: M Kachani; R L Spooner; P Rae; L Bell-Sakyi; C G Brown
Journal: Parasitol Res Date: 1992 Impact factor: 2.289

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Authors: P M Preston; C G Brown; R L Spooner
Journal: Clin Exp Immunol Date: 1983-07 Impact factor: 4.330

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Authors: Isaiah Obara; Morten Nielsen; Marie Jeschek; Ard Nijhof; Camila J Mazzoni; Nicholas Svitek; Lucilla Steinaa; Elias Awino; Cassandra Olds; Ahmed Jabbar; Peter-Henning Clausen; Richard P Bishop
Journal: Immunogenetics Date: 2016-02-06 Impact factor: 2.846

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Authors: K P Iams; R Hall; P Webster; A J Musoke
Journal: Infect Immun Date: 1990-06 Impact factor: 3.441

5. Preliminary studies on the effect of Anaplasma marginale antibodies ingested by Dermacentor andersoni ticks (Acari:Ixodidae) with their blood meal on infections in salivary glands.

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Journal: Exp Appl Acarol Date: 1996-06 Impact factor: 2.132

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Authors: D A Dobbelaere; S Z Shapiro; P Webster
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

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Authors: P Toye; J Nyanjui; B Goddeeris; A J Musoke
Journal: Infect Immun Date: 1996-05 Impact factor: 3.441