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Literature DB >> 6801655

Selective replication of ribosomal DNA repeats after loss of the abnormal oocyte phenotype in Drosophila melanogaster.

F Graziani, L Vicari, E Boncinelli, C Malva, A Manzi, C Mariani.

Abstract

Drosophila melanogaster females homozygous for the abnormal oocyte mutation produce a large excess of female offspring when crossed with XY/0 males. After several generations in abo homozygous stock, this maternal effect is no longer observed. The disappearance of the abo phenotype is coupled with an increase in the amount of DNA coding for rRNA (rDNA). We have used restriction endonuclease analysis of total DNA extracted from adult females and from single female larval brains to investigate the molecular organization of rDNA before and after the loss of abo phenotype. The rDNA increase is associated with variations of the restriction pattern of the nontranscribed spacer, probably due to a selective increase of rDNA repeats.

Entities: Gene Species

Mesh：

Substances：
RNA, Ribosomal

Year: 1981 PMID： 6801655 PMCID： PMC349329 DOI： 10.1073/pnas.78.12.7662

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

1. Ribosomal DNA in Drosophila melanogaster. II. Heteroduplex mapping of cloned and uncloned rDNA.

Authors: P K Wellauer; I B Dawid
Journal: J Mol Biol Date: 1978-12-25 Impact factor: 5.469

2. Ribosomal DNA in Drosophila melanogaster. I. Isolation and characterization of cloned fragments.

Authors: I B Dawid; P K Wellauer; E O Long
Journal: J Mol Biol Date: 1978-12-25 Impact factor: 5.469

3. The Regulation of Sex Chromosome Heterochromatic Activity by an Autosomal Gene in DROSOPHILA MELANOGASTER.

Authors: L Sandler
Journal: Genetics Date: 1970-03 Impact factor: 4.562

4. X and Y chromosomal ribosomal DNA of Drosophila: comparison of spacers and insertions.

Authors: P K Wellauer; I B Dawid; K D Tartof
Journal: Cell Date: 1978-06 Impact factor: 41.582

5. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors: P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

6. Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film.

Authors: R A Laskey; A D Mills
Journal: FEBS Lett Date: 1977-10-15 Impact factor: 4.124

7. Studies on the genetic control of heterochromatin in Drosophila melanogaster. Elizabeth Goldschmidt Memorial Lecture.

Authors: L Sandler
Journal: Isr J Med Sci Date: 1975-11

8. Analysis of the autosomal mutation abo and its interaction with the ribosomal DNA or Drosophila melanogaster: the role of X-chromosome heterochromatin.

Authors: B Yedvobnick; H M Krider; B I Levine
Journal: Genetics Date: 1980-07 Impact factor: 4.562

9. The effect of abo phenotypic expression on ribosomal DNA instabilities in Drosophila melanogaster.

Authors: H M Krider; B Yedvobnick; B I Levine
Journal: Genetics Date: 1979-07 Impact factor: 4.562

10. Long spacers among ribosomal genes of Drosophila melanogaster.

Authors: Z K Indik; K D Tartof
Journal: Nature Date: 1980-04-03 Impact factor: 49.962

7 in total

1. Complete reversion of the abo phenotype in D. melanogaster occurs only when the blood transposon is lost from region 32E.

Authors: V Cavaliere; F Graziani; S Andone; A Manzi; C Malva
Journal: Mol Gen Genet Date: 1991-12

Selective replication of ribosomal DNA repeats after loss of the abnormal oocyte phenotype in Drosophila melanogaster.

1. Ribosomal DNA in Drosophila melanogaster. II. Heteroduplex mapping of cloned and uncloned rDNA.

2. Ribosomal DNA in Drosophila melanogaster. I. Isolation and characterization of cloned fragments.

3. The Regulation of Sex Chromosome Heterochromatic Activity by an Autosomal Gene in DROSOPHILA MELANOGASTER.

4. X and Y chromosomal ribosomal DNA of Drosophila: comparison of spacers and insertions.

5. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

6. Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film.

7. Studies on the genetic control of heterochromatin in Drosophila melanogaster. Elizabeth Goldschmidt Memorial Lecture.

8. Analysis of the autosomal mutation abo and its interaction with the ribosomal DNA or Drosophila melanogaster: the role of X-chromosome heterochromatin.

9. The effect of abo phenotypic expression on ribosomal DNA instabilities in Drosophila melanogaster.

10. Long spacers among ribosomal genes of Drosophila melanogaster.

1. Complete reversion of the abo phenotype in D. melanogaster occurs only when the blood transposon is lost from region 32E.

2. Differential magnification of rDNA gene types in bobbed mutants of Drosophila melanogaster.

3. The abnormal oocyte phenotype is correlated with the presence of blood transposon in Drosophila melanogaster.

4. Nonselective amplification of ribosomal DNA repeat units in compensating genotypes of Drosophila melanogaster.

5. Expression of rDNA insertions during rDNA magnification in D. melanogaster.

6. X chromosome nucleolus organizer mutants which alter major type I repeat multiplicity in Drosophila melanogaster.

7. Developmental genetical analysis and molecular cloning of the abnormal oocyte gene of Drosophila melanogaster.