Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.

Swiss albino mice were treated twice daily with 200 mg/kg (i.p.) di-n-propylacetate (DPA), for 14 days and sacrificed 15 hr after the last injection, with or without an additional injection of 400 mg/kg at 45 min before death. Without the additional injection, the brain distribution of GABA followed closely that of control mice; with the additional injection, the pattern of regional increase of brain GABA was very similar to that following an acute injection of DPA. The anticonvulsant and antiaggressive properties of DPA were similar in rodents treated acutely or additionally after repeated DPA treatment. Neither the anticonvulsant nor the antiaggressive properties could be observed 15 hr after the last of the repeated injections of DPA. A residual effect of DPA against seizures induced by pentetrazole was shown, i.e. a potentiation of the anticonvulsant properties of the second of two successive injections of DPA, the latter being given after the decrease of the GABA levels in whole brain to control values.