Increased serum phospholipids in epileptic children treated with phenobarbitone.

Plasma lipid concentration and post-heparin lipolytic activity in twenty-two epileptic children treated either with phenobarbitone or sodium valproate were evaluated. An increase of phospholipid was observed in whole blood as well as in the low-density nd high-density lipoproteins in patients undergoing phenobarbitone treatment. No change was found in subjects treated with sodium valproate. The enzyme activities were slightly, but not statistically significantly, increased in the two groups compared with the control subjects.