Literature DB >> 6800033

A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene.

T Watabe, T Ishizuka, M Isobe, N Ozawa.   

Abstract

7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.

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Year:  1982        PMID： 6800033     DOI： 10.1126/science.6800033

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes.

Authors:  Hayrettin Ozan Gulcan; Michael W Duffel
Journal:  Arch Biochem Biophys       Date:  2010-12-25       Impact factor: 4.013

2.  Modification of the catalytic function of human hydroxysteroid sulfotransferase hSULT2A1 by formation of disulfide bonds.

Authors:  Xiaoyan Qin; Lynn M Teesch; Michael W Duffel
Journal:  Drug Metab Dispos       Date:  2013-02-26       Impact factor: 3.922

3.  Metabolism of amitriptyline in patients with chronic renal failure.

Authors:  M Sandoz; S Vandel; B Vandel; B Bonin; B Hory; Y St Hillier; R Volmat
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

4.  Selective alkylation of carcinogenic 9-anthryloxirane at the N-3 position of adenine in DNA.

Authors:  N C Yang; C W Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

5.  Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication.

Authors:  L M Weis; A M Rummel; S J Masten; J E Trosko; B L Upham
Journal:  Environ Health Perspect       Date:  1998-01       Impact factor: 9.031

6.  Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells.

Authors:  H Glatt; R Henschler; D H Phillips; J W Blake; P Steinberg; A Seidel; F Oesch
Journal:  Environ Health Perspect       Date:  1990-08       Impact factor: 9.031

7.  Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship.

Authors:  B L Upham; L M Weis; J E Trosko
Journal:  Environ Health Perspect       Date:  1998-08       Impact factor: 9.031

8.  Humoral immunosuppression in men exposed to polycyclic aromatic hydrocarbons and related carcinogens in polluted environments.

Authors:  A Szczeklik; J Szczeklik; Z Galuszka; J Musial; E Kolarzyk; D Targosz
Journal:  Environ Health Perspect       Date:  1994-03       Impact factor: 9.031
  8 in total

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