Literature DB >> 6799722

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations.

H Nau, R Zierer, H Spielmann, D Neubert, C Gansau.   

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Year:  1981        PMID: 6799722     DOI: 10.1016/0024-3205(81)90541-5

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


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  17 in total

Review 1.  Major malformations with valproic acid.

Authors:  Gideon Koren; Alejandro A Nava-Ocampo; Myla E Moretti; Reuven Sussman; Irena Nulman
Journal:  Can Fam Physician       Date:  2006-04       Impact factor: 3.275

2.  Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture.

Authors:  C Lewandowski; S Klug; H Nau; D Neubert
Journal:  Arch Toxicol       Date:  1986-04       Impact factor: 5.153

Review 3.  Principles and problems in assessing prenatal toxicity.

Authors:  D Neubert; I Chahoud; T Platzek; R Meister
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

4.  Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells.

Authors:  Miaoqing Shen; Rodica P Bunaciu; Johanna Congleton; Holly A Jensen; Lavanya G Sayam; Jeffrey D Varner; Andrew Yen
Journal:  Leuk Lymphoma       Date:  2011-08-24

5.  Behavioral teratogenicity of valproic acid: selective effects on behavior after prenatal exposure to rats.

Authors:  C V Vorhees
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 6.  Harnessing the clinical potential of antiepileptic drug therapy: dosage optimisation.

Authors:  E Perucca; O Dulac; S Shorvon; T Tomson
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

7.  Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets.

Authors:  J Vormann; V Höllriegl; H J Merker; T Günther
Journal:  Biol Trace Elem Res       Date:  1986-07       Impact factor: 3.738

8.  Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.

Authors:  B J Eickholt; G J Towers; W J Ryves; D Eikel; K Adley; L M J Ylinen; N H Chadborn; A J Harwood; H Nau; R S B Williams
Journal:  Mol Pharmacol       Date:  2005-02-01       Impact factor: 4.436

9.  Abnormal metabolism of valproic acid in fatal hepatic failure.

Authors:  W Kochen; A Schneider; A Ritz
Journal:  Eur J Pediatr       Date:  1983-10       Impact factor: 3.183

10.  The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice.

Authors:  R S Hauck; H Nau
Journal:  Pharm Res       Date:  1992-07       Impact factor: 4.200

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