Literature DB >> 6798115

Inhibition of antibody-dependent eosinophil-mediated cytotoxicity by heparin.

F Kierszenbaum, S J Ackerman, G J Gleich.   

Abstract

Killing of bloodstream forms of Trypanosoma cruzi, the unicellular parasite that causes Chagas' disease in humans, by human eosinophils in the presence of specific antibody to the parasite was inhibited by the polyanion heparin in a dose-dependent manner. The concentration of heparin required to completely abolish eosinophil-effected killing of the flagellate increased as the eosinophil to parasite ratio increased. These results suggest that antibody-dependent eosinophil-mediated cytotoxicity is mediated by basic constituents of the eosinophil granule.

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Year:  1982        PMID： 6798115

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  5 in total

Review 1.  Eosinophils in eosinophilic endomyocardial disease.

Authors:  C J Spry
Journal:  Postgrad Med J       Date:  1986-06       Impact factor: 2.401

2.  Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP.

Authors:  R L Barker; R H Gundel; G J Gleich; J L Checkel; D A Loegering; L R Pease; K J Hamann
Journal:  J Clin Invest       Date:  1991-09       Impact factor: 14.808

3.  Inhibition of eosinophils degranulation by Ketotifen in a patient with milk allergy, manifested as bronchial asthma--an electron microscopic study.

Authors:  W K Podleski; B A Panaszek; J L Schmidt; R B Burns
Journal:  Agents Actions       Date:  1984-10

4.  Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium.

Authors:  A Slungaard; G M Vercellotti; G Walker; R D Nelson; H S Jacob
Journal:  J Exp Med       Date:  1990-06-01       Impact factor: 14.307

5.  The mechanisms of cytotoxicity to tumor cells by polymorphonuclear leukocytes stimulated with cytokines.

Authors:  T Hayashi; S Arai; F Sendo
Journal:  Jpn J Cancer Res       Date:  1988-03
  5 in total

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