Literature DB >> 6798004

Fredericamycin A, a new antitumor antibiotic. I. Production, isolation and physicochemical properties.

R C Pandey, M W Toussaint, R M Stroshane, C C Kalita, A A Aszalos, A L Garretson, T T Wei, K M Byrne, R F Geoghegan, R J White.   

Abstract

A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described.

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Year:  1981        PMID： 6798004     DOI： 10.7164/antibiotics.34.1389

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  11 in total

1.  Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944.

Authors:  Yihua Chen; Evelyn Wendt-Pienkowski; Jianhua Ju; Shuangjun Lin; Scott R Rajski; Ben Shen
Journal:  J Biol Chem       Date:  2010-10-06       Impact factor: 5.157

Review 2.  Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.

Authors:  Christiana N Teijaro; Ajeeth Adhikari; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-13       Impact factor: 3.346

3.  In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases.

Authors:  Yihua Chen; Evelyn Wendt-Pienkoski; Scott R Rajski; Ben Shen
Journal:  J Biol Chem       Date:  2009-07-20       Impact factor: 5.157

4.  A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus.

Authors:  Ryan F Seipke; Jörg Barke; Charles Brearley; Lionel Hill; Douglas W Yu; Rebecca J M Goss; Matthew I Hutchings
Journal:  PLoS One       Date:  2011-08-03       Impact factor: 3.240

5.  Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D.

Authors:  Charles Dylan Turner; Marco A Ciufolini
Journal:  Beilstein J Org Chem       Date:  2011-10-28       Impact factor: 2.883

6.  Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology.

Authors:  Yonghe Zhang; Huiming Huang; Shanshan Xu; Bo Wang; Jianhua Ju; Huarong Tan; Wenli Li
Journal:  Microb Cell Fact       Date:  2015-05-01       Impact factor: 5.328

Review 7.  Spirocyclic Motifs in Natural Products.

Authors:  Evgeny Chupakhin; Olga Babich; Alexander Prosekov; Lyudmila Asyakina; Mikhail Krasavin
Journal:  Molecules       Date:  2019-11-17       Impact factor: 4.411

8.  Synthesis of Novel Spiro-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing.

Authors:  Yan-Cheng Liou; Yan-An Lin; Ke Wang; Juan-Cheng Yang; Yeong-Jiunn Jang; Wenwei Lin; Yang-Chang Wu
Journal:  Int J Mol Sci       Date:  2021-06-10       Impact factor: 5.923

9.  Novel Fredericamycin Variant Overproduced by a Streptomycin-resistant Streptomyces albus subsp. chlorinus Strain.

Authors:  Marta Rodríguez Estévez; Maksym Myronovskyi; Birgit Rosenkränzer; Thomas Paululat; Lutz Petzke; Jeanette Ristau; Andriy Luzhetskyy
Journal:  Mar Drugs       Date:  2020-05-28       Impact factor: 5.118

10.  Synthetic Approach to the ABCD Ring System of Anticancer Agent Fredericamycin A via Claisen Rearrangement and Ring-Closing Metathesis as Key Steps.

Authors:  Sambasivarao Kotha; Subba Rao Cheekatla; Ambareen Fatma
Journal:  ACS Omega       Date:  2019-10-14
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