Literature DB >> 6797085

Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children.

H J Neijens, T Wesselius, K F Kerrebijn.   

Abstract

The mechanism of exercise-induced bronchoconstriction (EIB) was studied by observing the protective effects of several aerosol agents in a double-blind, randomised trial. Exercise-induced bronchoconstriction was not affected by placebo, but was reduced by each agent used (p less than 0.001). Blocking the parasympathetic system had the weakest effect, while beta 2 adrenergic stimulation produced the strongest effect which was significantly different from the parasympatholytic (p less than 0.02). The effect of the mast cell stabilizer, sodium cromoglycate (SCG) was found to be intermediate. However in some patients SCG had a stronger effect than the beta 2 adrenergic agonist. A relationship was found between EIB and bronchial hyperreactivity induced by histamine (p less than 0.05).

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Year:  1981        PMID： 6797085      PMCID： PMC1020434          DOI： 10.1136/thx.36.7.517

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  21 in total

1.  Evaluation of lung function indices for bronchodilator trials. Results of a cross-over study of fenoterol.

Authors:  D Stănescu; R van Lemputten; A Frans; L Brasseur
Journal:  Respiration       Date:  1976       Impact factor: 3.580

2.  Bronchial reactivity to inhaled histamine: a method and clinical survey.

Authors:  D W Cockcroft; D N Killian; J J Mellon; F E Hargreave
Journal:  Clin Allergy       Date:  1977-05

3.  Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity.

Authors:  J Orehek; P Gayrard; A P Smith; C Grimaud; J Charpin
Journal:  Am Rev Respir Dis       Date:  1977-06

Review 4.  Disodium cromoglycate. Mode of action and its possible relevance to the clinical use of the drug.

Authors:  J S Cox
Journal:  Br J Dis Chest       Date:  1971-10

5.  Variability of bronchial reactivity to exercise and metacholine in bronchial asthma.

Authors:  J Kiviloog
Journal:  Scand J Respir Dis       Date:  1973

6.  Effect of disodium cromoglycate on exercise-induced asthma.

Authors:  S E Davies
Journal:  Br Med J       Date:  1968-09-07

Review 7.  Inhibition of exercise-induced asthma by different pharmacological pathways.

Authors:  S Godfrey; P König
Journal:  Thorax       Date:  1976-04       Impact factor: 9.139

8.  A standardized method of evaluating exercise-induced asthma.

Authors:  P A Eggleston; J L Guerrant
Journal:  J Allergy Clin Immunol       Date:  1976-09       Impact factor: 10.793

9.  Living histamine-containing cells from the bronchial lumens of humans. Description and comparison of histamine content with cells of rhesus monkeys.

Authors:  R Patterson; J M McKenna; I M Suszko; N H Solliday; J J Pruzansky; M Roberts; T J Kehoe
Journal:  J Clin Invest       Date:  1977-02       Impact factor: 14.808

10.  The effect of Sch 1000 and disodium cromoglycate on exercise-induced asthma.

Authors:  M Chan-Yeung
Journal:  Chest       Date:  1977-03       Impact factor: 9.410
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  8 in total

1.  Comparison of the bronchodilating effect of oxitropium bromide and fenoterol in asthmatic children.

Authors:  H P Van Bever; K N Desager; J H Pauwels; P A Vermeire
Journal:  Eur J Pediatr       Date:  1994-08       Impact factor: 3.183

Review 2.  Physical activity and child health.

Authors:  R J Shephard
Journal:  Sports Med       Date:  1984 May-Jun       Impact factor: 11.136

3.  Effect of 0.25 ppm nitrogen dioxide on the airway response to methacholine in asymptomatic asthmatic patients.

Authors:  R Jörres; H Magnussen
Journal:  Lung       Date:  1991       Impact factor: 2.584

Review 4.  Exercise and training in patients with chronic obstructive lung disease.

Authors:  N J Cox; C L van Herwaarden; H Folgering; R A Binkhorst
Journal:  Sports Med       Date:  1988-09       Impact factor: 11.136

5.  [Blockade of exercise-induced bronchial asthma by fenoterol].

Authors:  H Magnussen; G Reuss
Journal:  Klin Wochenschr       Date:  1984-02-15

6.  The bronchial response to cold air challenge: evidence for different mechanisms in normal and asthmatic subjects.

Authors:  R W Heaton; A F Henderson; B J Gray; J F Costello
Journal:  Thorax       Date:  1983-07       Impact factor: 9.139

7.  Comparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and ipratropium bromide on exercise-induced bronchoconstriction in children with asthma.

Authors:  A L Boner; I Antolini; A Andreoli; G De Stefano; L Sette
Journal:  Eur J Pediatr       Date:  1987-07       Impact factor: 3.183

Review 8.  Mast-cell stabilising agents to prevent exercise-induced bronchoconstriction.

Authors:  C H Spooner; G R Spooner; B H Rowe
Journal:  Cochrane Database Syst Rev       Date:  2003
  8 in total

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